Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks.
作者信息
Strittmatter Stephen M
机构信息
Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Nat Med. 2014 Jun;20(6):590-1. doi: 10.1038/nm.3595.
Abstract
摘要
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本文引用的文献
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Fyn kinase inhibition as a novel therapy for Alzheimer's disease.抑制Fyn激酶作为治疗阿尔茨海默病的新疗法。
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Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis.多相随机对照试验中头孢曲松治疗肌萎缩侧索硬化症的设计和初步结果。
PLoS One. 2013 Apr 17;8(4):e61177. doi: 10.1371/journal.pone.0061177. Print 2013.
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Second act: Drug repurposing gets a boost as academic researchers join the search for novel uses of existing drugs.第二幕：随着学术研究人员加入到寻找现有药物新用途的行列中，药物重新利用得到了推动。
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Diagnosing the decline in pharmaceutical R&D efficiency.诊断制药研发效率下降。
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Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury.小分子诱导的 Rho 抑制：脊髓损伤后的 NSAIDs。
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Trends in risks associated with new drug development: success rates for investigational drugs.新药研发相关风险趋势：研究药物的成功率。
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Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth.布洛芬通过限制组织损失和刺激轴突生长来促进脊髓损伤的恢复。
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N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.N-（5-氯-1,3-苯并二氧杂环戊烯-4-基）-7-[2-（4-甲基哌嗪-1-基）乙氧基]-5-（四氢-2H-吡喃-4-基氧基）喹唑啉-4-胺，一种新型、高度选择性、口服可用的双特异性c-Src/Abl激酶抑制剂。
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