Zivkovic Piero Marin, Matetic Andrija, Tadin Hadjina Ivana, Rusic Doris, Vilovic Marino, Supe-Domic Daniela, Borovac Josip Andelo, Mudnic Ivana, Tonkic Ante, Bozic Josko
Department of Gastroenterology, University Hospital of Split, 21000 Split, Croatia.
Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.
J Clin Med. 2020 Feb 26;9(3):628. doi: 10.3390/jcm9030628.
Catestatin (CST) is an important peptide in the pathophysiology of chronic inflammatory disorders. However, clinical studies on inflammatory bowel disease (IBD) patients are lacking. Our goal was to investigate CST concentrations in IBD patients compared to healthy subjects. Additionally, we aimed to determine arterial stiffness parameters in relation to CST. This cross-sectional study compared 80 IBD patients (45 Crohn's disease (CD) and 35 ulcerative colitis (UC) patients) with 75 control subjects. Serum CST levels were significantly higher in the IBD group compared to control subjects (11.29 ± 9.14 vs. 7.13 ± 6.08 ng/mL, 0.001) and in the UC group compared to CD patients (13.50 ± 9.58 vs. 9.03 ± 6.92 ng/mL, 0.021), irrespective of age and BMI. IBD patients exhibited significantly higher values of heart rate adjusted central augmentation index (cAIx-75) (14.88 ± 10.59 vs. 6.87 ± 9.50 %, 0.001) and pulse wave velocity (PWV) (8.06 ± 3.23 vs. 6.42 ± 1.47 m/s, 0.001) compared to control group. Furthermore, PWV was the only significant independent correlate of CST ( 1.20, 4.15, 0.001), while CST, PWV, cAIx-75, high-sensitivity C-reactive protein and BMI were significant predictors of positive IBD status (1.089 (1.022-1.161), 1.515 (1.166-1.968), 1.060 (1.024-1.097), 1.458 (1.116-1.906), 0.793 (0.683-0.920), respectively). Serum CST levels were significantly higher in IBD patients compared to controls and an independent positive correlation of CST with PWV existed. Therefore, it is possible that CST could have a role in the complex pathophysiology of IBD and its cardiovascular complications.
抑制素（CST）是慢性炎症性疾病病理生理学中的一种重要肽。然而，针对炎症性肠病（IBD）患者的临床研究尚缺乏。我们的目标是研究IBD患者与健康受试者相比的CST浓度。此外，我们旨在确定与CST相关的动脉僵硬度参数。这项横断面研究将80例IBD患者（45例克罗恩病（CD）和35例溃疡性结肠炎（UC）患者）与75名对照受试者进行了比较。与对照受试者相比，IBD组的血清CST水平显著更高（11.29±9.14对7.13±6.08 ng/mL，P<0.001），与CD患者相比，UC组的血清CST水平也显著更高（13.50±9.58对9.03±6.92 ng/mL，P = 0.021），且不受年龄和体重指数的影响。与对照组相比，IBD患者的心率校正中心增强指数（cAIx-75）（14.88±10.59对6.87±9.50%，P<0.001）和脉搏波速度（PWV）（8.06±3.23对6.42±1.47 m/s，P<0.001）的值显著更高。此外，PWV是CST的唯一显著独立相关因素（β = 1.20，95%CI：4.15，P<0.001），而CST、PWV、cAIx-75、高敏C反应蛋白和体重指数是IBD阳性状态的显著预测因素（分别为1.089（1.022 - 1.161）、1.515（1.166 - 1.968）、1.060（1.024 - 1.097）、1.458（1.116 - 1.906）、0.793（0.683 - 0.920））。与对照组相比，IBD患者的血清CST水平显著更高，且CST与PWV存在独立正相关。因此，CST可能在IBD及其心血管并发症的复杂病理生理学中发挥作用。
