Ghorbanihaghjo Amir, Javadzadeh Alireza, Rashtchizadeh Nadereh, Sorkhabi Rana, Khalili Hasan, Rahimi-Ardabili Babak
Department of Ophthalmology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Ophthalmology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Acta Med Iran. 2014;52(4):265-70.
Calcification and inflammation are among the important cases of exudative age-related macular degeneration (E-ARMD). The aim of the present study was to elucidate if there is any relationship between serum Osteoprotegerin (OPG), soluble receptor activator of nuclear factor-kappa B ligand (RANK-ligand) and E-ARMD. In a cross-sectional study, we compared 45 E-ARMD patients with 45 matched controls. Diagnosis was confirmed by fluorescein angiography. Serum samples were analyzed for OPG, RANK-ligand, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG). The levels of OPG and RANK-ligand were measured by ELISA methods. The mean age was 72.0±11.5 years in the E-ARMD group and 68.2±8.9 years in the control group (p=0.09). The level of serum OPG was 132.10±75.49 pg/ml in the E-ARMD group and 94.88±61.65 pg/ml in the control subjects. E-ARMD patients had significantly high levels of OPG (p=0.012), as well as significantly high levels of LDL-C and TC (p=0.001 and p=0.005, respectively). We could not find any significant difference in RANK-ligand, HDL-C, or TG between two study groups (p>0.05). To the best of our knowledge, this is the first study investigating the levels of OPG in E-ARMD patients. The present study showed that E-ARMD patients had high levels of serum OPG. It may act as a protective factor for E-ARMD or only as a secondary phenomenon of different processes of E-ARMD. Further prospective studies would be necessary for prognostic and predictive significance of OPG in patients affected by E-ARMD.
钙化和炎症是渗出性年龄相关性黄斑变性（E-ARMD）的重要病例。本研究的目的是阐明血清骨保护素（OPG）、可溶性核因子κB受体活化因子配体（RANK-配体）与E-ARMD之间是否存在任何关联。在一项横断面研究中，我们将45例E-ARMD患者与45例匹配的对照进行了比较。通过荧光素血管造影术确诊。对血清样本进行了OPG、RANK-配体、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）和甘油三酯（TG）分析。采用酶联免疫吸附测定（ELISA）方法测量OPG和RANK-配体水平。E-ARMD组的平均年龄为72.0±11.5岁，对照组为68.2±8.9岁（p = 0.09）。E-ARMD组血清OPG水平为132.10±75.49 pg/ml，对照组为94.88±61.65 pg/ml。E-ARMD患者的OPG水平显著升高（p = 0.012），LDL-C和TC水平也显著升高（分别为p = 0.001和p = 0.005）。我们未发现两个研究组在RANK-配体、HDL-C或TG方面存在任何显著差异（p>0.05）。据我们所知，这是第一项研究E-ARMD患者OPG水平的研究。本研究表明，E-ARMD患者血清OPG水平较高。它可能是E-ARMD的保护因子，或者仅是E-ARMD不同过程的继发现象。对于OPG在E-ARMD患者中的预后和预测意义，还需要进一步的前瞻性研究。
