Stevenson Mario
University of Miami Medical School, Miami, FL, USA.
Top Antivir Med. 2014 May;22(2):574-8.
In the HIV basic science categories of the 2014 Conference on Retroviruses and Opportunistic Infections, research examining obstacles to viral eradication continued to be a major component. This research encompassed areas of activity from the identification of where virus resides in individuals on suppressive antiretroviral therapy to studies aimed at eliminating long-lived viral reservoirs that persist in the face of therapy. In the area of antiviral restrictions, a number of presentations highlighted the ability of host factors to profoundly shape the interplay between virus and host and, in particular, how innate immune response opposes viral infection through the induction of antiviral restrictions.
在2014年逆转录病毒与机会性感染会议的HIV基础科学类别中，研究病毒根除障碍的研究仍是一个主要组成部分。这项研究涵盖了从确定接受抑制性抗逆转录病毒治疗的个体中病毒的存在位置到旨在消除面对治疗仍持续存在的长寿病毒储存库的研究等多个活动领域。在抗病毒限制领域，一些报告强调了宿主因素深刻塑造病毒与宿主之间相互作用的能力，特别是先天免疫反应如何通过诱导抗病毒限制来对抗病毒感染。
