Hogan Carys, Le Noury Joanna, Healy David, Mangin Derelie
North Wales Department of Psychological Medicine, Bangor, Wales, UK.
David Braley & Nancy Gordon Chair of Family Medicine, Department of Family Medicine, McMaster University, ON, Canada.
Int J Risk Saf Med. 2014;26(2):109-16. doi: 10.3233/JRS-140617.
There have been reports for over a decade linking serotonin reuptake inhibitors, finasteride and isotretinoin with enduring sexual dysfunction after treatment stops.
To explore the clinical pictures linked to all 3 drugs.
We have selected 120 reports to RxISK.org reporting the problem and mined these for data on age, gender, drug of use, and impact of the problem.
The data make it clear that the three drugs show extensive overlap in symptom profile, regardless of sex or country of origin.
The availability of 120 reports from over 20 countries add to the case for the validity of the syndrome. This is severe and enduring condition can result in death. An understanding of its physiology and an approach to treatment are needed.
十多年来一直有报告称，血清素再摄取抑制剂、非那雄胺和异维甲酸在治疗停止后会导致持久的性功能障碍。
探究与这三种药物相关的临床症状。
我们从RxISK.org网站挑选了120份报告，这些报告均提及了该问题，并从中挖掘了有关年龄、性别、所用药物以及该问题影响的数据。
数据表明，无论性别或原产国如何，这三种药物在症状表现上有广泛重叠。
来自20多个国家的120份报告进一步证明了该综合征的真实性。这种严重且持久的状况可能导致死亡。因此需要了解其生理机制并找到治疗方法。
