Hwang Seung Ook, Lee Sang-Woo, Kang Jin Koo, Choi Hyang Hee, Kim Wan Wook, Park Ho Yong, Jung Jin Hyang
Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
Department of Nuclear Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Otolaryngol Head Neck Surg. 2014 Sep;151(3):415-20. doi: 10.1177/0194599814537224. Epub 2014 Jun 5.
This study evaluates the relationship between visually identifiable (18)F-fluorodeoxyglucose (FDG) uptake in primary papillary thyroid microcarcinoma (PTMC) and tumor aggressiveness.
Historical cohort study.
Tertiary care center.
Clinicopathological factors and PET/CT findings of 219 PTMC surgical patients who underwent preoperative (18)F-FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed.
(18)F-FDG uptake was observed in the tumors of 124 (56.6%) patients. Tumor size (odds ratio [OR] = 1.774; 95% confidence interval [CI], 1.416-2.223; P < .0001) and Hashimoto thyroiditis (OR = 2.815; CI, 1.237-6.404; P = .014) independently predicted (18)F-FDG uptake. Tumor size (OR = 1.495; CI, 1.217-1.835; P < .0001) and BRAF(V600E) mutation (OR = 3.320; CI, 1.056-10.432; P = .040) independently predicted extrathyroidal invasion. Multiplicity (OR = 2.375; CI, 1.278-4.415; P = .006) independently predicted central lymph node metastasis.
(18)F-FDG uptake in PTMC depends on tumor size and Hashimoto thyroiditis. Therefore, preoperative PET/CT for PTMC may not help in evaluating tumor aggressiveness.
本研究评估原发性甲状腺微小乳头状癌（PTMC）中视觉可识别的（18）F-氟脱氧葡萄糖（FDG）摄取与肿瘤侵袭性之间的关系。
回顾性队列研究。
三级医疗中心。
回顾性分析219例接受术前（18）F-FDG正电子发射断层扫描/计算机断层扫描（PET/CT）的PTMC手术患者的临床病理因素和PET/CT检查结果。
124例（56.6%）患者的肿瘤中观察到（18）F-FDG摄取。肿瘤大小（优势比[OR]=1.774；95%置信区间[CI]，1.416-2.223；P<.0001）和桥本甲状腺炎（OR=2.815；CI，1.237-6.404；P=.014）独立预测（18）F-FDG摄取。肿瘤大小（OR=1.495；CI，1.217-1.835；P<.0001）和BRAF（V600E）突变（OR=3.320；CI，1.056-10.432；P=.040）独立预测甲状腺外侵犯。肿瘤多灶性（OR=2.375；CI，1.278-4.415；P=.006）独立预测中央淋巴结转移。
PTMC中的（18）F-FDG摄取取决于肿瘤大小和桥本甲状腺炎。因此，PTMC的术前PET/CT可能无助于评估肿瘤侵袭性。
