血小板转录景观之旅。
A tour through the transcriptional landscape of platelets.
作者信息
Schubert Sebastian, Weyrich Andrew S, Rowley Jesse W
机构信息
The Molecular Medicine Program and.
The Molecular Medicine Program and Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.
出版信息
Blood. 2014 Jul 24;124(4):493-502. doi: 10.1182/blood-2014-04-512756. Epub 2014 Jun 5.
Abstract
The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.
摘要
血小板内发现的RNA编码及其编码的改变，持续为血小板功能及功能障碍的机制基础提供线索。现已明确，血小板中信使RNA（mRNA）的特征与有核细胞的特征相似。这篇综述为有兴趣深入了解血小板mRNA的读者充当导游。此次“游览”对血小板mRNA进行了深入且互动式的审视，尤其是在新一代RNA测序的背景下。在此次探索之旅结束时，读者将能更好地掌握血小板mRNA的全貌，以及它在健康和疾病状态下如何影响血小板功能。
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