Rojas J, Rivero A, Cisneros J M, Alonso L, Alba E, Pachón J
Departamento de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla.
Enferm Infecc Microbiol Clin. 1989 Nov;7(9):482-4.
We present four patients with Hodgkin's disease and human immunodeficiency virus infection (HIV). Three patients were addicts to parenteral drugs. The disease was very advanced at the time of diagnosis, stage IVB in all cases. Histologic types were mixed cellularity in two cases, nodular sclerosis in one case and it was not typifiable in the remaining case. The disturbances of cell-mediated immunity that the patients presented were those of the acquired immunodeficiency syndrome (AIDS) as well as the infectious complications. Response to treatment was poor with a high incidence of bone marrow toxicity; three patients died during the first 3 months after the diagnosis (X = 7.3 months). We emphasize the necessity of considering different prognostic and therapeutic approaches for the HD in these patients in contrast with those of seronegative patients. We pose some questions suggested by the review of the literature and the data of this series.
我们报告了4例患有霍奇金病和人类免疫缺陷病毒感染（HIV）的患者。3例患者为静脉注射毒品成瘾者。诊断时疾病已处于非常晚期，所有病例均为IVB期。组织学类型2例为混合细胞型，1例为结节硬化型，其余1例无法分型。患者出现的细胞介导免疫紊乱为获得性免疫缺陷综合征（AIDS）以及感染性并发症。治疗反应较差，骨髓毒性发生率高；3例患者在诊断后的前3个月内死亡（平均 = 7.3个月）。我们强调，与血清学阴性患者相比，对于这些患者的霍奇金病需要考虑不同的预后和治疗方法。我们提出了一些由文献综述和本系列数据引发的问题。
