Rubio García R, Yebra Bango M, Alvarez de Mon Soto M, Costa Pérez-Herrero R, España Saz P, Torroba Alvarez L, Buzón Rueda L, Serrano Comino M, Durántez Martínez A
Med Clin (Barc). 1989 Jun 3;93(1):1-4.
Nine young males with Hodgkin's disease (HD) and antibodies against the human immunodeficiency virus were evaluated. They had been diagnosed since 1984 in three Madrid hospitals: Hospital 12 de Octubre, Hospital Ramón y Cajal, and Clínica Puerta de Hierro. Eight patients were intravenous heroin abusers and one was homosexual. In 8 patients (88.8%) HD presented in advanced stages (III and IV), and in 5 cases (55.5%) the histology corresponded to mixed cell type. Four patients (44.4%) developed opportunistic infections. In the immunological study a reduction of CD4+ lymphocytes below 0.4 X 10(3)/l was found in 5 of 7 patients (71.4%), and an inversion of CD4+/CD8+ ratio in 6 of 7 patients (85.7%). The response to therapy was poor. Five patients died (55.5%). In 4, the direct cause of death was an opportunistic infection. The reasons why we think that HD in patients with HIV infections should be considered as indicating acquired immunodeficiency syndrome are discussed.
对9名患有霍奇金病（HD）且携带人类免疫缺陷病毒抗体的年轻男性进行了评估。他们自1984年起在马德里的三家医院被诊断出来：十月十二日医院、拉蒙·卡哈尔医院和铁之门诊所。8名患者为静脉注射海洛因成瘾者，1名患者为同性恋者。8名患者（88.8%）的HD处于晚期（III期和IV期），5例（55.5%）的组织学类型为混合细胞型。4名患者（44.4%）发生了机会性感染。在免疫学研究中，7名患者中有5名（71.4%）的CD4+淋巴细胞减少至低于0.4×10³/μl，7名患者中有6名（85.7%）的CD4+/CD8+比值倒置。治疗反应较差。5名患者死亡（55.5%）。其中4名患者的直接死因是机会性感染。文中讨论了为何我们认为HIV感染患者的HD应被视为获得性免疫缺陷综合征的指征。
