对毒品说“不”：禁食可保护造血干细胞免受化疗和衰老影响。
Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.
作者信息
Hine Christopher, Mitchell James R
机构信息
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Cell Stem Cell. 2014 Jun 5;14(6):704-5. doi: 10.1016/j.stem.2014.05.016.
Abstract
Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.
摘要
衰老和化疗药物会损害造血干细胞（HSCs），导致不对称分裂失调，进而引发免疫抑制和血液相关疾病。在本期中，Cheng等人（2014年）采用长时间禁食作为一种医学干预手段，以降低IGF-1/PKA信号传导，保护造血干细胞免受化疗毒性影响，并促进其年轻化。
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本文引用的文献
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2
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