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对毒品说“不”：禁食可保护造血干细胞免受化疗和衰老影响。

Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.

作者信息

Hine Christopher, Mitchell James R

机构信息

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Cell Stem Cell. 2014 Jun 5;14(6):704-5. doi: 10.1016/j.stem.2014.05.016.

DOI:10.1016/j.stem.2014.05.016
PMID:24905161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4278638/
Abstract

Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.

摘要

衰老和化疗药物会损害造血干细胞（HSCs），导致不对称分裂失调，进而引发免疫抑制和血液相关疾病。在本期中，Cheng等人（2014年）采用长时间禁食作为一种医学干预手段，以降低IGF-1/PKA信号传导，保护造血干细胞免受化疗毒性影响，并促进其年轻化。

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本文引用的文献

1
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.长期禁食可降低胰岛素样生长因子-1/蛋白激酶A，以促进基于造血干细胞的再生并逆转免疫抑制。
Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014.
2
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.静止的造血干细胞在衰老过程中积累DNA损伤，这些损伤在进入细胞周期时会被修复。
Cell Stem Cell. 2014 Jul 3;15(1):37-50. doi: 10.1016/j.stem.2014.04.016. Epub 2014 May 8.
3
Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis.化疗诱导的免疫抑制性髓系细胞通过 PD-1-PD-L1 轴减弱抗肿瘤 CD4+ T 细胞反应。
Cancer Res. 2014 Jul 1;74(13):3441-53. doi: 10.1158/0008-5472.CAN-13-3596. Epub 2014 Apr 29.
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Benefits of short-term dietary restriction in mammals.哺乳动物短期节食的益处。
Exp Gerontol. 2013 Oct;48(10):1043-8. doi: 10.1016/j.exger.2013.01.009. Epub 2013 Feb 1.
5
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.BCL-2 抑制作用靶向氧化磷酸化并选择性根除静止期人类白血病干细胞。
Cell Stem Cell. 2013 Mar 7;12(3):329-41. doi: 10.1016/j.stem.2012.12.013. Epub 2013 Jan 17.
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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.人类骨髓造血干细胞随着年龄的增长而频率增加，并偏向髓系。
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Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.饥饿依赖性差异抗逆性保护正常细胞而非癌细胞免受高剂量化疗的影响。
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