Pirooz Sara, He Shanshan, O'Connell Douglas, Khalilzadeh Payam, Yang Yongfei, Liang Chengyu
Department of Molecular Microbiology and Immunology; University of Southern California; Los Angeles, CA USA.
Autophagy. 2014 Jul;10(7):1355-6. doi: 10.4161/auto.29075. Epub 2014 May 15.
While the cell imposes multiple barriers to virus entry, enveloped viruses are remarkably still able to gain entry to their cellular hosts by hitchhiking and remodeling the endomembrane system to traffic within, and eventually escape from, endosomal organelles for their genome release. Elucidating viral entry mechanisms and their interaction with the host trafficking network is necessary for antiviral therapy. Here, we focus on the use of host autophagy molecular factors during the entry of prototypic negative-stranded RNA viruses, and highlight recent progress in our understanding of the role of one such factor, UVRAG, in both viral and cellular endocytic membrane trafficking and fusion events.
虽然细胞对病毒进入设置了多重障碍，但包膜病毒仍能通过搭乘和重塑内膜系统，在内体细胞器内运输并最终从中逃逸以释放其基因组，从而成功进入细胞宿主。阐明病毒进入机制及其与宿主运输网络的相互作用对抗病毒治疗至关重要。在此，我们聚焦于原型负链RNA病毒进入过程中宿主自噬分子因子的作用，并着重介绍了我们对其中一个因子UVRAG在病毒和细胞内吞膜运输及融合事件中的作用的最新认识进展。
