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本文引用的文献

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Stimulation of systemic low-grade inflammation by psychosocial stress.心理社会压力对全身低度炎症的刺激。
Psychosom Med. 2014 Apr;76(3):181-9. doi: 10.1097/PSY.0000000000000049.
2
First-episode psychosis: an inflammatory state?首发精神病：炎症状态？
Neuroimmunomodulation. 2014;21(2-3):102-8. doi: 10.1159/000356536. Epub 2014 Feb 14.
3
Changes in pro-inflammatory cytokines and body weight during 6-month risperidone treatment in drug naïve, first-episode schizophrenia.初发未用药的精神分裂症患者在接受6个月利培酮治疗期间促炎细胞因子和体重的变化
Psychopharmacology (Berl). 2014 Jan;231(2):319-25. doi: 10.1007/s00213-013-3382-4. Epub 2013 Dec 14.
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A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis.首发精神病患者下丘脑-垂体-肾上腺轴活性的系统评价
Psychoneuroendocrinology. 2013 May;38(5):603-11. doi: 10.1016/j.psyneuen.2012.12.025. Epub 2013 Jan 28.
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Stress abnormalities in individuals at risk for psychosis: a review of studies in subjects with familial risk or with "at risk" mental state.处于精神病风险中的个体的应激异常：具有家族风险或“处于风险中”精神状态的受试者研究综述。
Psychoneuroendocrinology. 2012 Oct;37(10):1600-13. doi: 10.1016/j.psyneuen.2012.05.003. Epub 2012 Jun 2.
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Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume.压力和炎症会降低首发精神病患者脑源性神经营养因子的表达：导致海马体体积减小的一种途径。
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Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects.精神分裂症细胞因子变化的荟萃分析：临床状况和抗精神病作用。
Biol Psychiatry. 2011 Oct 1;70(7):663-71. doi: 10.1016/j.biopsych.2011.04.013. Epub 2011 Jun 8.
8
Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis.皮质醇和脱氢表雄酮硫酸盐水平与首发精神病患者的症状严重程度相关。
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Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis.初发精神病患者未用药时对急性应激的神经内分泌和免疫反应受损。
Schizophr Bull. 2012 Mar;38(2):272-9. doi: 10.1093/schbul/sbq062. Epub 2010 Jun 17.
10
Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis.初发精神病患者皮质醇觉醒反应异常预示认知功能更差。
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从压力到精神病：对象是谁、如何发生、何时发生以及为何发生？

From stress to psychosis: whom, how, when and why?

作者信息

Mondelli V

机构信息

Department of Psychological Medicine,King's College London, Institute of Psychiatry,London,UK.

出版信息

Epidemiol Psychiatr Sci. 2014 Sep;23(3):215-8. doi: 10.1017/S204579601400033X. Epub 2014 Jun 6.

DOI:10.1017/S204579601400033X
PMID:24905592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6998263/
Abstract

The role of stress in precipitating the onset and relapse of psychosis has been now widely recognised. Over the past decade, the major challenge of research in this field has been to elucidate the biological mechanisms involved in the interaction between stress and psychosis onset. Obvious focus of this research has been the study of biological systems involved in the stress response. I will here briefly discuss the current evidence of abnormalities in stress biomarkers, such as cortisol and inflammatory markers, in patients with psychosis and their possible clinical implications. Stress biomarkers appear to hold strong potential as predictors of psychosis as well as of clinical outcome, and may represent optimal targets for the development of novel therapeutic agents for psychosis.

摘要

压力在促使精神病发作和复发方面所起的作用如今已得到广泛认可。在过去十年中，该领域研究的主要挑战一直是阐明压力与精神病发作之间相互作用所涉及的生物学机制。这项研究的明显重点一直是对应激反应所涉及的生物系统进行研究。在此，我将简要讨论精神病患者压力生物标志物（如皮质醇和炎症标志物）异常的当前证据及其可能的临床意义。压力生物标志物似乎具有很强的潜力，可作为精神病以及临床结果的预测指标，并且可能代表开发新型精神病治疗药物的最佳靶点。