一种快速灵敏的定量测定人血液和血浆中左丙氧芬的方法。 - Suppr | 超能文献

A rapid and sensitive method for the quantitation of levoprotiline in human blood and plasma.

作者信息

Jedrychowski M, Hoffmann E, Bieck P R

机构信息

Human Pharmacology Institute, CIBA-GEIGY GmbH, Tuebingen, FRG.

出版信息

J Pharm Biomed Anal. 1989;7(12):1897-901. doi: 10.1016/0731-7085(89)80211-0.

DOI:10.1016/0731-7085(89)80211-0

Abstract

摘要

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A rapid and sensitive method for the quantitation of levoprotiline in human blood and plasma.一种快速灵敏的定量测定人血液和血浆中左丙氧芬的方法。

J Pharm Biomed Anal. 1989;7(12):1897-901. doi: 10.1016/0731-7085(89)80211-0.

2

Determination of the antidepressant levoprotiline and its N-desmethyl metabolite in biological fluids by gas chromatography/mass spectrometry.气相色谱/质谱法测定生物样品中抗抑郁药左丙替林及其N-去甲基代谢物

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3

Fluorimetric determination of levoprotiline in human plasma after thin-layer chromatographic or high performance liquid chromatographic separation.薄层色谱或高效液相色谱分离后荧光法测定人血浆中的左丙氧芬。

Arzneimittelforschung. 1987 Oct;37(10):1179-81.

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Pharmacokinetics of the antidepressant levoprotiline after intravenous and peroral administration in healthy volunteers.健康志愿者静脉注射和口服抗抑郁药左普替林后的药代动力学

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Assay for maprotiline in human serum with improved sensitivity and selectivity.用于人血清中马普替林的检测，具有更高的灵敏度和选择性。

J Chromatogr B Biomed Appl. 1994 Jun 3;656(1):245-9. doi: 10.1016/0378-4347(94)00071-9.

6

[Results of a clinical trial of levoprotiline].[左丙氧芬临床试验结果]

Cesk Psychiatr. 1992 Jun;88(2):97-105.

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Measurement of maprotiline and oxaprotiline in plasma by high-performance liquid chromatography of fluorescent derivatives.采用荧光衍生物高效液相色谱法测定血浆中的马普替林和奥沙普替林。

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Pharmacological profile of the new antidepressant levoprotiline.

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Pharmaco-EEG profile of levoprotiline: second example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.左普替林的药物脑电图特征：讨论药物脑电图在精神活性药物早期人体药理学评估中预测价值的第二个实例。

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[Dynamics of the effects of levoprotiline and maprotiline on EEG in patients with major depressive episodes (DSM-III-R)].[左丙氧芬和马普替林对重度抑郁发作患者（DSM-III-R）脑电图的影响动态]

Cesk Psychiatr. 1993 Jun;89(3):123-9.

引用本文的文献

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Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not alpha 2-adrenoceptor binding to intact platelets in man.奥沙普替林：静脉注射胺类升压试验表明其具有对去甲肾上腺素摄取的对映体选择性抑制作用，但对人体完整血小板的α2-肾上腺素受体结合无此作用。

Eur J Clin Pharmacol. 1993;44(1):93-5. doi: 10.1007/BF00315288.

2

Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine.马普替林的代谢似乎与由基因决定的异喹胍CYP2D6多态性羟基化共同分离。

Br J Clin Pharmacol. 1994 Apr;37(4):383-8. doi: 10.1111/j.1365-2125.1994.tb04293.x.