采用荧光衍生物高效液相色谱法测定血浆中的马普替林和奥沙普替林。
Measurement of maprotiline and oxaprotiline in plasma by high-performance liquid chromatography of fluorescent derivatives.
作者信息
Breyer-Pfaff U, Wiatr R, Nill K
出版信息
J Chromatogr. 1984 Jul 13;309(1):107-14. doi: 10.1016/0378-4347(84)80010-9.
PMID:6480757
Abstract
The antidepressant maprotiline and its hydroxylated analogue oxaprotiline were assayed in plasma by solvent extraction and formation of fluorescent derivatives, which were purified by thin-layer chromatography and quantitated by high-performance liquid chromatography with fluorescence monitoring. The procedure possesses a high sensitivity, accuracy and reproducibility, and metabolites of the drugs did not interfere.
摘要
采用溶剂萃取和荧光衍生物形成法对血浆中的抗抑郁药马普替林及其羟基化类似物奥沙普替林进行测定，通过薄层色谱法对荧光衍生物进行纯化，并用带荧光监测的高效液相色谱法进行定量分析。该方法具有高灵敏度、准确性和重现性，且药物代谢物不产生干扰。
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