Gammella Elena, Buratti Paolo, Cairo Gaetano, Recalcati Stefania
Department of Biomedical Sciences for Health, University of Milan, Via Mangiagalli 31, 20133 Milano, Italy.
Metallomics. 2014 Aug;6(8):1336-45. doi: 10.1039/c4mt00104d.
Macrophages are important to immune function and also actively participate in iron homeostasis. The involvement of splenic and liver macrophages in the processing of effete erythrocytes and the subsequent return of iron to the circulation is well established, and the molecular details of iron recycling have been characterized recently. Another important aspect regarding iron handling by macrophages is their capacity to act as immune cells, which involves the inflammatory response, as well as other pathological conditions in which macrophages are central. This review discusses the latest advances in macrophage iron trafficking and the pathophysiological consequences of altered iron homeostasis in these cells.
巨噬细胞对免疫功能至关重要，并且还积极参与铁稳态的维持。脾脏和肝脏巨噬细胞参与衰老红细胞的处理以及随后铁返回循环的过程已得到充分证实，并且铁循环的分子细节最近也已得到表征。巨噬细胞处理铁的另一个重要方面是它们作为免疫细胞的能力，这涉及炎症反应以及巨噬细胞起核心作用的其他病理状况。本文综述了巨噬细胞铁转运的最新进展以及这些细胞中铁稳态改变的病理生理后果。
