Wang Su-Fang, Shu Long, Wang Shuai, Wang Xiao-Qin, Mu Min, Hu Chun-Qiu, Liu Kai-Yong, Zhao Qi-Hong, Hu An-La, Bo Qing-Li, Tao Fang-Biao, Sheng Jie
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University , Hefei, Anhui , China.
Blood Press. 2014 Dec;23(6):339-44. doi: 10.3109/08037051.2014.906131. Epub 2014 Jun 6.
In this study, we report the relationship between hyperuricemia and hypertension in a middle-aged Chinese population, emphasizing the difference of gender. The cross-sectional study was conducted among 1776 adults aged 45-60 years, who participated in the Hefei Nutrition and Health Study (2012). Hyperuricemia was defined as serum uric acid (SUA)> 420 μmol/l for men, and > 360 μmol/l for women. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg. Anthropometric measurements and biochemical data were collected using standardized procedures. Multivariate logistic regression analysis was performed to determine the relationship between hyperuricemia and hypertension with adjustment of potential confounding factors. Body mass index (BMI), waist circumference (WC), SBP, DBP, fasting glucose, SUA and the prevalence of hyperuricemia and hypertension were significantly higher in male than in female (p < 0.001). Females had significantly higher levels of triglycerides (TG) and high-density lipoprotein (HDL)-cholesterol (5.23 ± 0.87 vs 5.12 ± 1.01, p < 0.05, 1.50 ± 0.37 vs 1.28 ± 0.41, respectively.) than males. Simple correlation analysis showed that SUA was positively associated with WC and TG. In addition, after adjusting for potential confounders, hyperuricemia was associated with increased risk of hypertension in both males and females, with odds ratios (95% CI) of 1.680 (1.110-2.543) and 1.065 (1.012-1.118), respectively. Conclusions: The association of hyperuricemia with hypertension was stronger in males than in females, and middle-aged men with hyperuricemia had greater association with hypertension. Our findings remain to be confirmed in future prospective studies.
在本研究中，我们报告了中国中年人群中高尿酸血症与高血压之间的关系，并强调了性别差异。这项横断面研究在1776名年龄在45至60岁之间、参加了合肥营养与健康研究（2012年）的成年人中进行。高尿酸血症定义为男性血清尿酸（SUA）>420μmol/l，女性>360μmol/l。高血压定义为收缩压（SBP）≥140mmHg或舒张压（DBP）≥90mmHg。使用标准化程序收集人体测量数据和生化数据。进行多变量逻辑回归分析以确定高尿酸血症与高血压之间的关系，并对潜在的混杂因素进行调整。男性的体重指数（BMI）、腰围（WC）、SBP、DBP、空腹血糖、SUA以及高尿酸血症和高血压的患病率均显著高于女性（p<0.001）。女性的甘油三酯（TG）和高密度脂蛋白（HDL）-胆固醇水平显著高于男性（分别为5.23±0.87对5.12±1.01，p<0.05；1.50±0.37对1.28±0.41）。简单相关性分析表明，SUA与WC和TG呈正相关。此外，在调整潜在混杂因素后，高尿酸血症与男性和女性患高血压风险的增加均相关，优势比（95%CI）分别为1.680（1.110-2.543）和1.065（1.012-1.118）。结论：高尿酸血症与高血压的关联在男性中比在女性中更强，中年高尿酸血症男性与高血压的关联更大。我们的研究结果有待未来前瞻性研究进一步证实。
