Department of Surgical Nursing, School of Nursing, Jinzhou Medical University, No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province, People's Republic of China.
Department of Occupational and Environmental Health, Key Laboratory of Occupational Health and Safety for Coal Industry in Hebei Province, School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, People's Republic of China.
BMC Cardiovasc Disord. 2020 Apr 15;20(1):174. doi: 10.1186/s12872-020-01468-3.
The purpose of the research was to explore the extent of interaction between triglycerides (TG) and serum uric acid (SUA) level with blood pressure (BP) in middle-aged and elderly individuals in China.
Data were selected from the China Health and Retirement Longitudinal Study (CHARLS), a cross-sectional study. 3345(46.99%) men with average ages of 60.24 ± 9.24 years and 3774 (53.01%) women with average ages of 59.91 ± 9.95 years were included in the study. Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, A general linear model adjusted for confounding factors (socio-demographic characteristics [age, educational levels, marital status, place of residence], health behaviors [cigarette smoking, alcohol drinking, eating habits, social and leisure activities, accidental injury, physical activities], medical history [history of cardiovascular diseases, hepatitis history, antidiabetic drugs, history of antilipidemic medication, anti-hypertensive therapy], metabolic measures [C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR), body mass index (BMI)]) was used to examine the synergistic effect of SUA and TG level on BP in middle-aged and elderly individuals in China.
Age-adjusted partial Pearson's correlation coefficient showed that SUA and TG level positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both men and women. Multiple linear regression analysis showed the TG level was significantly and positively associated with SBP and DBP in both men (SBP: β =0.068, P = 0.001; DBP: β =0.064, P = 0.002) and women (SBP: β =0.061, P = 0.002; DBP: β =0.084, P = 0.000), but SUA were significantly and positively associated with SBP in both men (SBP: β =0.047, P = 0.013) and women (SBP: β =0.040, P = 0.028), regardless of other confounding factors. After adjusting for related potential confounders, evidence of interaction between SUA and TG level on SBP (men: β = - 1.090, P = 0.726; women: β = - 0.692, P = 0.861) and DBP (men: β = - 1.026, P = 0.572; women: β = - 0.794, P = 0.842) was not observed.
The interaction effect of SUA and TG level on BP was not observed in our study. Moreover, high SUA level was significantly associated with SBP, while high TG level was strongly related to both DBP and SBP.
本研究旨在探讨中国中老年人的甘油三酯（TG）和血清尿酸（SUA）水平与血压（BP）之间的相互作用程度。
数据来自中国健康与退休纵向研究（CHARLS），这是一项横断面研究。研究共纳入了 3345 名男性（平均年龄 60.24±9.24 岁）和 3774 名女性（平均年龄 59.91±9.95 岁）。通过 t 检验或卡方检验评估性别或血压水平类别之间的差异。首先，使用线性回归模型比较各种特征与 BP 状态之间的调整关联，根据需要进行调整。然后，使用调整混杂因素（社会人口统计学特征[年龄、教育水平、婚姻状况、居住地点]、健康行为[吸烟、饮酒、饮食习惯、社交和休闲活动、意外伤害、体力活动]、既往病史[心血管疾病史、肝炎史、降糖药、调脂药史、抗高血压治疗]、代谢指标[C 反应蛋白（CRP）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、估计肾小球滤过率（eGFR）、体重指数（BMI）]）的一般线性模型来检验中国中老年人中 SUA 和 TG 水平对 BP 的协同作用。
年龄调整的部分 Pearson 相关系数显示，SUA 和 TG 水平与男性和女性的收缩压（SBP）和舒张压（DBP）均呈正相关。多元线性回归分析显示，TG 水平与男性（SBP：β=0.068，P=0.001；DBP：β=0.064，P=0.002）和女性（SBP：β=0.061，P=0.002；DBP：β=0.064，P=0.002）的 SBP 和 DBP 呈显著正相关，但 SUA 与男性（SBP：β=0.047，P=0.013）和女性（SBP：β=0.040，P=0.028）的 SBP 呈显著正相关，无论其他混杂因素如何。在调整相关潜在混杂因素后，SUA 和 TG 水平对 SBP（男性：β=-1.090，P=0.726；女性：β=-0.692，P=0.861）和 DBP（男性：β=-1.026，P=0.572；女性：β=-0.794，P=0.842）的交互作用无统计学意义。
在本研究中，未观察到 SUA 和 TG 水平对 BP 的交互作用。此外，高 SUA 水平与 SBP 显著相关，而高 TG 水平与 DBP 和 SBP 均密切相关。
