三联拳出击，消灭胞内菌。

Delivering three punches to knockout intracellular bacteria.

机构信息

Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France.

Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France; Service d'Immunologie, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13285 Marseille, France.

出版信息

Cell. 2014 Jun 5;157(6):1251-1252. doi: 10.1016/j.cell.2014.05.023.

DOI:10.1016/j.cell.2014.05.023

PMID:24906142

Abstract

Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.

摘要

细胞毒性淋巴细胞能杀死受细菌感染的细胞，但具体作用机制尚不清楚。Walch 等人的研究表明，这些淋巴细胞通过两步过程传递一种毒性三联体分子，首先穿透受感染的细胞，然后将杀菌颗粒酶递送到细胞内的细菌中。