Ransing Ramdas S, Gupta Neha, Agrawal Girish, Mahapatro Nilima
Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, Maharashtra, India.
Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.
J Neurosci Rural Pract. 2020 Apr;11(2):261-266. doi: 10.1055/s-0040-1703422. Epub 2020 Mar 17.
Panic disorder (PD) is associated with changes in platelet and red blood cell (RBC) indices. However, the diagnostic or predictive value of these indices is unknown. This study assessed the diagnostic and discriminating value of platelet and RBC indices in patients with PD. In this cross-sectional study including patients with PD ( = 98) and healthy controls ( = 102), we compared the following blood indices: mean platelet volume (MPV), platelet distribution width (PDW), and RBC distribution width (RDW). The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUC), sensitivity, specificity, and likelihood ratio for the platelet and RBC indices. Statistically significant increase in PDW (17.01 ± 0.91 vs. 14.8 ± 2.06; < 0.0001) and RDW (16.56 ± 2.32 vs. 15.12 ± 2.43; < 0.0001) levels were observed in patients with PD. PDW and mean corpuscular hemoglobin concentration had larger AUC (0.89 and 0.74, respectively) and Youden's index (0.65 and 0.39, respectively), indicating their higher predictive capacity as well as higher sensitivity in discriminating patients with PD from healthy controls. PDW can be considered a "good" diagnostic or predictive marker in patients with PD.
惊恐障碍（PD）与血小板和红细胞（RBC）指标的变化有关。然而，这些指标的诊断或预测价值尚不清楚。本研究评估了血小板和红细胞指标在惊恐障碍患者中的诊断和鉴别价值。
在这项横断面研究中，纳入了98例惊恐障碍患者和102例健康对照者，我们比较了以下血液指标：平均血小板体积（MPV）、血小板分布宽度（PDW）和红细胞分布宽度（RDW）。采用受试者工作特征（ROC）曲线来计算血小板和红细胞指标的ROC曲线下面积（AUC）、敏感性、特异性和似然比。
观察到惊恐障碍患者的PDW水平（17.01±0.91 vs. 14.8±2.06；P<0.0001）和RDW水平（16.56±2.32 vs. 15.12±2.43；P<0.0001）有统计学意义的升高。PDW和平均红细胞血红蛋白浓度具有较大的AUC（分别为0.89和0.74）和尤登指数（分别为0.65和0.39），表明它们在鉴别惊恐障碍患者与健康对照者时具有较高的预测能力和敏感性。
PDW可被视为惊恐障碍患者的一个“良好”诊断或预测标志物。
