癌症与阿尔茨海默病之间的关联：系统评价与荟萃分析。
Association between cancer and Alzheimer's disease: systematic review and meta-analysis.
作者信息
Ma Ling-Li, Yu Jin-Tai, Wang Hui-Fu, Meng Xiang-Fei, Tan Chen-Chen, Wang Chong, Tan Lan
机构信息
Department of Neurology, Qingdao Municipal Hospital, Weifang Medical University, Shandong, China.
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Shandong, China Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Shandong, China.
出版信息
J Alzheimers Dis. 2014;42(2):565-73. doi: 10.3233/JAD-140168.
This study examined the association between cancer and Alzheimer's disease (AD) by a quantitative meta-analysis of cohort studies. Studies were identified by searching PubMed database through 1966 to December 2013 using the terms "Alzheimer's disease", "neoplasm", and "cancer". Six studies met the inclusion criteria in the overall meta-analysis. We pooled effect sizes using fixed-effects and random-effects models. Furthermore, we also tested for heterogeneity and publication bias. The results suggested that individuals diagnosed with AD had a decreased risk for incident cancer by 42% (95% CI, 0.40-0.86; p < 0.05), and patients with a history of cancer had a 37% decreased risk of AD (RR = 0.63; 95% CI, 0.56-0.72; p = 0.495). The Egger's test for publication bias (p = 0.280) showed no significant evidence for bias in the data from studies on AD and cancer risk. In summary, our meta-analysis demonstrated an inverse association between cancer and AD.
本研究通过对队列研究进行定量荟萃分析，探讨了癌症与阿尔茨海默病（AD）之间的关联。通过使用“阿尔茨海默病”、“肿瘤”和“癌症”等术语，检索1966年至2013年12月的PubMed数据库来识别研究。在总体荟萃分析中，有六项研究符合纳入标准。我们使用固定效应模型和随机效应模型合并效应量。此外，我们还检验了异质性和发表偏倚。结果表明，被诊断为AD的个体患新发癌症的风险降低了42%（95%CI，0.40 - 0.86；p < 0.05），有癌症病史的患者患AD的风险降低了37%（RR = 0.63；95%CI，0.56 - 0.72；p = 0.495）。Egger发表偏倚检验（p = 0.280）表明，关于AD和癌症风险的研究数据中没有显著的偏倚证据。总之，我们的荟萃分析表明癌症与AD之间存在负相关。
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