Bosch J, Borja F, Alvarez E, Carbonell X
Enferm Infecc Microbiol Clin. 1989 Jan;7(1):40-3.
The epidemiological, clinical and bacteriological data of 38 infants under 28 days of age with a diagnosis of neonatal meningitis (13 patients), early neonatal sepsis (17 patients) or late neonatal sepsis (8 patients) were retrospectively reviewed. 52.6% of patients were premature and/or low weight neonates, 76.3% had an unfavorable obstetrical history and 39.4% had one or more underlying diseases. The clinical features were predominantly neurological (81.5%), cardiac or respiratory (71%) and gastrointestinal (34.2); the most outstanding laboratory data were positive CRP, hyperbilirubinemia and abnormalities in leukocyte differential count. The major microorganisms involved were E. coli (11 patients), S. agalactiae (9), S. aureus (5), L. monocytogenes (3) and coagulase-negative Staphylococcus (3). The overall incidence of these disorders was 3.33 cases/1000 live neonates, and the mortality rate was 7.9%.
回顾性分析了38例28日龄以下诊断为新生儿脑膜炎（13例）、早发型新生儿败血症（17例）或晚发型新生儿败血症（8例）婴儿的流行病学、临床和细菌学数据。52.6%的患者为早产儿和/或低体重儿，76.3%有不良产科史，39.4%有一种或多种基础疾病。临床特征主要为神经系统症状（81.5%）、心脏或呼吸系统症状（71%）和胃肠道症状（34.2%）；最突出的实验室数据为CRP阳性、高胆红素血症和白细胞分类计数异常。主要病原菌包括大肠杆菌（11例）、无乳链球菌（9例）、金黄色葡萄球菌（5例）、单核细胞增生李斯特菌（3例）和凝固酶阴性葡萄球菌（3例）。这些疾病的总发病率为3.33例/1000例活产新生儿，死亡率为7.9%。
