地舒单抗治疗骨巨细胞瘤的放射学和病理学特征。

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima-shi, Fukushima 960-1295, Japan.

Diagn Pathol. 2014 Jun 7;9:111. doi: 10.1186/1746-1596-9-111.

UNLABELLED

We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and 18F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells.

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未注明

我们描述了一例 20 岁男性胫骨近端巨细胞瘤伴同侧股骨骨转移跳跃。在接受地舒单抗新辅助治疗后，平片和 CT 显示明显的骨质硬化和硬化环形成，18F-FDG PET/CT 显示标准摄取值降低，而磁共振成像显示肿瘤弥漫性增强，与治疗前几乎相同。地舒单抗治疗后的手术标本的病理检查显示良性纤维组织细胞瘤样特征，单核基质细胞和多核破骨细胞样巨细胞完全消失。