Choufi B, Thiant S, Trauet J, Cliquennois M, Cherrel M, Boulanger F, Coiteux V, Magro L, Labalette M, Yakoub-Agha I
EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'hématologie, center hospitalier de Boulogne-sur-mer, BP 609, 62321 Boulogne-sur-mer cedex, France.
EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
Pathol Biol (Paris). 2014 Jun;62(3):123-8. doi: 10.1016/j.patbio.2014.02.013. Epub 2014 Jun 3.
In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7(+)/CD4(+) T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7(+)/CCR7(neg) ratio of CD4(+) T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation.
在之前一项针对62例接受HLA匹配的异基因干细胞移植患者的前瞻性研究中，我们观察到移植物中供体来源的CCR7(+)/CD4(+) T细胞比例可作为急性移植物抗宿主病（GVHD）的预测指标，且不会影响慢性GVHD和复发率。在此，我们展示了对137例连续患者的验证队列研究结果。实际上，移植物中接受超过76% CCR7(+)/CD4(+) T细胞的患者，无论低级别还是高级别急性GVHD的发生率都高于未接受该比例细胞的患者。测定移植物中CD4(+) T细胞的CCR7(+)/CCR7(neg) 比例可作为急性GVHD的预测指标，并有助于确定部分选择性T细胞去除移植的策略。
