Téllez A, Bernal A, de Ory F, Estévez E, Martínez-Martín P, Barreiro G, Martín F P, Echevarría J M
Enferm Infecc Microbiol Clin. 1989 Feb;7(2):77-82.
The experience with the virological diagnosis of lymphocytic meningitis in the Centro Nacional de Microbiología during 3 years (1984-1986) included 632 cases. The most common causative organism was the parotiditis virus (46.9%), particularly in children (64.6%), followed by the non-polio enteroviruses (25.3%). The varicella-zoster virus was the most common organism found in adults (33.3%). We describe some clinical and epidemiological aspects, emphasizing the absence of clinical features suggesting herpesvirus infection in about 50% of cases. Finally, we indicate the study techniques or methods more adequate in each instance (specific IgM detection, isolation techniques or detection of intrathecal antibody production), and we define a study protocol for cases of acute lymphocytic meningitis which permits a high diagnostic yield (44.1-54.9%).
国家微生物中心在3年（1984 - 1986年）间对淋巴细胞性脑膜炎进行病毒学诊断的经验涵盖了632例病例。最常见的致病病原体是腮腺炎病毒（46.9%），在儿童中尤为常见（64.6%），其次是非脊髓灰质炎肠道病毒（25.3%）。水痘 - 带状疱疹病毒是在成人中最常见的病原体（33.3%）。我们描述了一些临床和流行病学方面的情况，强调约50%的病例缺乏提示疱疹病毒感染的临床特征。最后，我们指出了在每种情况下更合适的研究技术或方法（特异性IgM检测、分离技术或鞘内抗体产生的检测），并为急性淋巴细胞性脑膜炎病例定义了一个研究方案，该方案具有较高的诊断率（44.1 - 54.9%）。
