Hammarfjord Oscar, Stassen Leo F A
National Maxillofacial Unit, St James's Hospital, Dublin, Ireland.
Professor, National Maxillofacial Unit, St James's Hospital, Dublin, Ireland.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Sep;118(3):e68-70. doi: 10.1016/j.oooo.2014.02.011. Epub 2014 Feb 22.
Bisphosphonates are an effective class of drugs used for various pathologies of bone tissues such as osteoporosis and solid malignant metastatic disease. Although reports on adverse events such as bisphosphonate-induced osteonecrosis of the jaw are common, ankylosis of the temporomandibular joint in an older patient that is possibly associated with bisphosphonate treatment has not, to our knowledge, been previously reported. The patient, a 70-year-old woman with none of the usual causes for ankylosis, presented with bilateral ankylosis to the temporomandibular joints on a background of bisphosphonate treatment. No obvious etiologic factor for the bilateral ankylosis was found; thus, this might represent another complication of bisphosphonate therapy that dentists and physicians need to be aware of. The approach to management of the ankylosis is described.
双膦酸盐是一类有效的药物，用于治疗各种骨组织疾病，如骨质疏松症和实体恶性转移性疾病。尽管关于双膦酸盐引起的颌骨坏死等不良事件的报道很常见，但据我们所知，老年患者颞下颌关节强直且可能与双膦酸盐治疗相关的情况此前尚未有报道。该患者为一名70岁女性，不存在导致关节强直的常见病因，在接受双膦酸盐治疗的背景下出现双侧颞下颌关节强直。未发现双侧关节强直的明显病因；因此，这可能代表了双膦酸盐治疗的另一种并发症，牙医和医生需要对此有所了解。本文描述了关节强直的处理方法。
