Piet Richard, de Croft Simon, Liu Xinhuai, Herbison Allan E
Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Front Neuroendocrinol. 2015 Jan;36:15-27. doi: 10.1016/j.yfrne.2014.05.006. Epub 2014 Jun 5.
Kisspeptin neurons are critical components of the neuronal network controlling the activity of the gonadotropin-releasing hormone (GnRH) neurons. A variety of genetically-manipulated mouse models have recently facilitated the study of the electrical activity of the two principal kisspeptin neuron populations located in the rostral periventricular area of the third ventricle (RP3V) and arcuate nucleus (ARN) in acute brain slices. We discuss here the mechanisms and pathways through which kisspeptin neurons regulate GnRH neuron activity. We then examine the different kisspeptin-green fluorescent protein mouse models being used for kisspeptin electrophysiology and the data obtained to date for RP3V and ARN kisspeptin neurons. In light of these new observations on the spontaneous firing rates, intrinsic membrane properties, and neurotransmitter regulation of kisspeptin neurons, we speculate on the physiological roles of the different kisspeptin populations.
kisspeptin神经元是控制促性腺激素释放激素（GnRH）神经元活动的神经网络的关键组成部分。最近，各种基因操作小鼠模型有助于研究位于第三脑室室周前部区域（RP3V）和弓状核（ARN）的两个主要kisspeptin神经元群体在急性脑片中的电活动。我们在此讨论kisspeptin神经元调节GnRH神经元活动的机制和途径。然后，我们研究用于kisspeptin电生理学的不同kisspeptin-绿色荧光蛋白小鼠模型以及迄今为止获得的关于RP3V和ARN kisspeptin神经元的数据。鉴于对kisspeptin神经元的自发放电率、内在膜特性和神经递质调节的这些新观察结果，我们推测不同kisspeptin群体的生理作用。
