Kim Kyoung Min, Lim Sung-Kil
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Curr Opin Pharmacol. 2014 Jun;16:133-41. doi: 10.1016/j.coph.2014.05.001. Epub 2014 Jun 5.
MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3'-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
微小RNA（miRNA）是一类非编码单链RNA，通过与靶基因的3'非翻译区结合来调控其表达。miRNA是多种生物学过程的重要调节因子，包括细胞分化、增殖、凋亡和组织发育。此外，miRNA表达异常已成为包括骨质疏松症在内的多种人类疾病的重要发病机制。因此，miRNA的治疗潜力最近引起了极大关注。在这里，我们重点研究了miRNA在骨稳态中的作用以及miRNA作为治疗靶点的潜力。
