IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Bone. 2019 May;122:52-75. doi: 10.1016/j.bone.2019.02.013. Epub 2019 Feb 14.
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.
微小 RNA（miRNA）已被证明可以增强或抑制不同类型的骨组织细胞的增殖、分化和活性。miRNA 作用及其靶标的发现有助于将其鉴定为骨内新的调控因子。多项研究表明，miRNA 失调介导了与骨相关的病理过程的进展，如骨质疏松症。本综述旨在全面概述涉及骨稳态且具有实验验证靶点的 miRNA，并强调它们在骨质疏松症发展中的可能作用。此外，该综述分析了临床试验中发现的与骨质疏松症相关的 miRNA。
