T 细胞在体内完整淋巴结中的迁移。

T cell migration in intact lymph nodes in vivo.

机构信息

Centenary Institute of Cancer Medicine and Cell Biology, Immune Imaging Program, Locked Bag 6, Newtown, NSW 2042, Australia.

Centenary Institute of Cancer Medicine and Cell Biology, Immune Imaging Program, Locked Bag 6, Newtown, NSW 2042, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.

出版信息

Curr Opin Cell Biol. 2014 Oct;30:17-24. doi: 10.1016/j.ceb.2014.05.002. Epub 2014 Jun 5.

DOI:10.1016/j.ceb.2014.05.002

PMID:24907445

Abstract

In the lymph node, T cells migrate rapidly and with striking versatility in a continuous scan for antigen presenting dendritic cells. The scanning process is greatly facilitated by the lymph node structure and composition. In vivo imaging has been instrumental in deciphering the spatiotemporal dynamics of intranodal T cell migration in both health and disease. Here we review recent developments in uncovering the migration modes employed by T cells in the lymph node, the underlying molecular mechanisms, and the scanning strategies utilised by T cells to ensure a timely response to antigenic stimuli.

摘要

在淋巴结中，T 细胞在快速且显著多样化地扫描抗原呈递树突状细胞，以寻找抗原。淋巴结的结构和组成极大地促进了这一扫描过程。体内成像在解析健康和疾病状态下淋巴结内 T 细胞迁移的时空动态方面发挥了重要作用。在这里，我们综述了揭示 T 细胞在淋巴结中采用的迁移模式、潜在分子机制以及 T 细胞用于确保对抗原刺激及时响应的扫描策略方面的最新进展。