Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran; School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA; School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA.
Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:168-77. doi: 10.1016/j.msec.2014.04.039. Epub 2014 Apr 26.
The high corrosion rate of Mg alloys has hindered their application in various areas, particularly for orthopedic applications. In order to decrease the corrosion rate and to improve the bioactivity, mechanical stability and cytocompatibility of the Mg alloy, nanostructured diopside (CaMgSi2O6) has been coated on AZ91 Mg alloy using a combined micro arc oxidation (MAO) and electrophoretic deposition (EPD) method. The crystalline structure, the morphology and the composition of the samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electrochemical corrosion test, immersion test, and compression test were used to evaluate the corrosion resistance, the in vitro bioactivity and the mechanical stability of the samples, respectively. The cytocompatibility of the samples was tested by the cell viability and the cell attachment of L-929 cells. The results confirmed that the diopside coating not only slows down the corrosion rate, but also enhances the in vitro bioactivity, mechanical stability and cytocompatibility of AZ91 Mg alloy. Therefore, Mg alloy coated with nanostructured diopside offers a promising approach for biodegradable bone implants.
镁合金的高腐蚀速率阻碍了它们在各个领域的应用，特别是在骨科应用方面。为了降低镁合金的腐蚀速率，并提高其生物活性、机械稳定性和细胞相容性，采用微弧氧化（MAO）和电泳沉积（EPD）相结合的方法，在 AZ91 镁合金上涂覆了纳米结构的透辉石（CaMgSi2O6）。通过 X 射线衍射（XRD）、扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）对样品的晶体结构、形貌和组成进行了表征。电化学腐蚀试验、浸泡试验和压缩试验分别用于评估样品的耐腐蚀性、体外生物活性和机械稳定性。通过 L-929 细胞的细胞活力和细胞附着来测试样品的细胞相容性。结果证实，透辉石涂层不仅可以减缓腐蚀速率，还可以增强 AZ91 镁合金的体外生物活性、机械稳定性和细胞相容性。因此，涂覆纳米结构透辉石的镁合金为可生物降解的骨植入物提供了一种有前途的方法。
