Zivadinov Robert, Chin Jamie, Horakova Dana, Bergsland Niels, Weinstock-Guttman Bianca, Tamaño-Blanco Miriam, Badgett Darlene, Hagemeier Jesper, Tyblova Michaela, Carl Ellen, Krasensky Jan, Vaneckova Manuela, Seidl Zdenek, Dwyer Michael G, Havrdova Eva, Ramanathan Murali
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA; Department of Neurology, State University of New York, Buffalo, NY, USA.
Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA.
J Neuroimmunol. 2014 Aug 15;273(1-2):58-64. doi: 10.1016/j.jneuroim.2014.04.012. Epub 2014 Apr 30.
To investigate the associations between antibody responses to herpesviruses and the development of thalamic, total deep gray matter, cortical and central atrophy in high-risk clinically isolated syndromes (CIS) after the first demyelinating event.
We analyzed volumetric brain outcomes in 193 CIS patients enrolled in a multi-center study of high-risk CIS. All patients had 2 or more MRI brain lesions and two or more oligoclonal bands in cerebrospinal fluid. Serum samples obtained at the screening visit prior to any treatment were analyzed for IgG antibodies against cytomegalovirus (anti-CMV) and Epstein-Barr virus (EBV) viral capsid antigen (VCA). All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months.
Anti-EBV VCA highest quartile status was associated with regional atrophy measures for percent decrease in thalamus. Anti-CMV positivity was associated with greater total deep gray matter atrophy and whole brain atrophy. Anti-EBV VCA highest quartile status was associated as trends with greater whole brain, gray matter atrophy and central atrophy. The associations of anti-EBV VCA antibodies with thalamic atrophy were mediated by its associations with T2 lesions whereas the associations of anti-CMV positivity with deep gray matter atrophy were relatively independent of T2 lesions.
Antibody responses to EBV and CMV are associated with global and regional brain atrophy in CIS patients treated with interferon-beta.
研究首次脱髓鞘事件后高危临床孤立综合征（CIS）患者中针对疱疹病毒的抗体反应与丘脑、全深部灰质、皮质及中枢萎缩发展之间的关联。
我们分析了193例参与高危CIS多中心研究的CIS患者的脑容量结果。所有患者在脑脊液中有2个或更多的MRI脑病变和2个或更多的寡克隆带。对在任何治疗前的筛查访视时采集的血清样本进行分析，检测针对巨细胞病毒（抗CMV）和爱泼斯坦-巴尔病毒（EBV）病毒衣壳抗原（VCA）的IgG抗体。所有患者均接受β-干扰素治疗。在基线、6个月、12个月和24个月时进行临床和MRI评估。
抗EBV VCA处于最高四分位数状态与丘脑百分比下降的区域萎缩测量值相关。抗CMV阳性与更大程度的全深部灰质萎缩和全脑萎缩相关。抗EBV VCA处于最高四分位数状态与更大程度的全脑、灰质萎缩和中枢萎缩呈趋势性相关。抗EBV VCA抗体与丘脑萎缩的关联是通过其与T2病变的关联介导的，而抗CMV阳性与深部灰质萎缩的关联相对独立于T2病变。
在接受β-干扰素治疗的CIS患者中，针对EBV和CMV的抗体反应与全脑和区域脑萎缩相关。
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