Xu Yu, Zhang Ji-Xiang
Department of Otolaryngology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China,
Eur Arch Otorhinolaryngol. 2015 Mar;272(3):597-605. doi: 10.1007/s00405-014-3130-3. Epub 2014 Jun 8.
Several polymorphisms in a disintegrin and metalloproteinase 33 (ADAM33) have been implicated in susceptibility to allergic rhinitis (AR), but the results are inconclusive. This meta-analysis was aimed to clarify the impact of ADAM33 polymorphisms on AR risk. Pubmed, EMBASE and Cochrane library were searched until 11 October 2013 for eligible studies on seven ADAM33 polymorphisms: T1, T2, S1, S2, V4, Q-1 and T+1. Data were extracted, and pooled odd ratios (ORs) as well as 95 % confidence intervals (CIs) were calculated. Six studies with 1,135 AR patients and 1,565 controls were included. It was found that ADAM33 T1 (AG+GG vs. AA, OR 1.47, 95 % CI 1.23-1.75, I (2) = 94 %; G vs. A, OR 1.53, 95 % CI 1.32-1.78, I (2) = 94 %), T2 (GA+AA vs. GG, OR 1.26, 95 % CI 1.06-1.51, I (2) = 92 %; G vs. A, OR 1.27, 95 % CI 1.08-1.50, I (2) = 92 %), V4 (CG+GG vs. CC OR 1.35, 95 % CI 1.14-1.59, I (2) = 95 %;G vs. C OR 1.28, 95 % CI 1.13-1.44, I (2) = 96 %) and Q-1 (GA+AA vs. GG OR 1.55, 95 % CI 1.24-1.95, I (2) = 74 %; G vs. C OR 1.46, 95 % CI 1.19-1.79, I (2) = 73 %) polymorphisms were significantly associated with AR susceptibility but not S1, S2 and T+1. In Asians, the same result was found. This meta-analysis indicated that ADAM33 T1, T2, V4 and Q-1 polymorphisms may be the risk factors which conferred to AR susceptibility. The differences in ethnicity did not influence the associations obviously. Gene-gene and gene-environment interactions should be investigated in the future.
解整合素金属蛋白酶33（ADAM33）中的几种多态性与过敏性鼻炎（AR）易感性有关，但结果尚无定论。本荟萃分析旨在阐明ADAM33多态性对AR风险的影响。检索了PubMed、EMBASE和Cochrane图书馆，直至2013年10月11日，以查找有关7种ADAM33多态性的合格研究：T1、T2、S1、S2、V4、Q - 1和T + 1。提取数据并计算合并比值比（OR）以及95%置信区间（CI）。纳入了6项研究，共1135例AR患者和1565例对照。发现ADAM33 T1（AG + GG与AA相比，OR 1.47，95%CI 1.23 - 1.75，I² = 94%；G与A相比，OR 1.53，95%CI 1.32 - 1.78，I² = 94%）、T2（GA + AA与GG相比，OR 1.26，95%CI 1.06 - 1.51，I² = 92%；G与A相比，OR 1.27，95%CI 1.08 - 1.50，I² = 92%）、V4（CG + GG与CC相比，OR 1.35，95%CI 1.14 - 1.59，I² = 95%；G与C相比，OR 1.28，95%CI 1.13 - 1.44，I² = 96%）和Q - 1（GA + AA与GG相比，OR 1.55，95%CI 1.24 - 1.95，I² = 74%；G与C相比，OR 1.46，95%CI 1.19 - 1.79，I² = 73%）多态性与AR易感性显著相关，而S1、S2和T + 1则不然。在亚洲人中也发现了相同的结果。本荟萃分析表明，ADAM33 T1、T2、V4和Q - 1多态性可能是导致AR易感性的危险因素。种族差异对这些关联的影响不明显。未来应研究基因 - 基因和基因 - 环境相互作用。
