Motoya Tadasu, Matsumoto Seiji, Yamaguchi Satoshi, Wada Naoki, Numata Atsushi, Osanai Hiroaki, Kakizaki Hidehiro
Department of Renal and Urologic Surgery, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan.
Int Urol Nephrol. 2014 Oct;46(10):1877-81. doi: 10.1007/s11255-014-0757-3. Epub 2014 Jun 8.
To investigate the impact of abdominal aortic calcification and visceral fat area (VFA) on lower urinary tract symptoms (LUTS) and clinical parameters in patients with benign prostatic hyperplasia (BPH).
We retrospectively studied 250 patients with LUTS associated with BPH. Each participant was examined with routine examination including measurement of various data; (1) voided volume (VV), maximum urinary flow rate on free uroflowmetry, (2) postvoid residual urine volume and prostate volume using transabdominal ultrasound, (3) International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS), and (4) aortic calcification index (ACI) and VFA were measured by abdominal CT.
Mean age of the patients was 72.4 ± 9.6 years. ACI significantly correlated with VV (P = 0.0392) and tended to correlate with maximum urinary flow rate, while ACI did not correlate with subjective symptoms. VFA significantly correlated with nocturia score of IPSS (P = 0.0177) and frequency score of OABSS (P = 0.0166) and tended to correlate with urgency score of IPSS and maximum urinary flow rate.
Aortic calcification index (ACI) correlated with only objective parameters, while VFA correlated with only storage symptoms. This study suggested that abdominal aortic calcification and VFA have certain influence on LUTS and clinical parameters in patients with BPH.
探讨腹主动脉钙化和内脏脂肪面积（VFA）对良性前列腺增生（BPH）患者下尿路症状（LUTS）及临床参数的影响。
我们回顾性研究了250例伴有BPH的LUTS患者。对每位参与者进行常规检查，包括测量各种数据；（1）排尿量（VV）、自由尿流率测定时的最大尿流率，（2）经腹部超声测量排尿后残余尿量和前列腺体积，（3）国际前列腺症状评分（IPSS）和膀胱过度活动症症状评分（OABSS），以及（4）通过腹部CT测量主动脉钙化指数（ACI）和VFA。
患者的平均年龄为72.4±9.6岁。ACI与VV显著相关（P = 0.0392），并倾向于与最大尿流率相关，而ACI与主观症状无关。VFA与IPSS的夜尿评分（P = 0.0177）和OABSS的尿频评分（P = 0.0166）显著相关，并倾向于与IPSS的尿急评分和最大尿流率相关。
主动脉钙化指数（ACI）仅与客观参数相关，而VFA仅与储尿期症状相关。本研究表明，腹主动脉钙化和VFA对BPH患者的LUTS及临床参数有一定影响。
