Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Int J Urol. 2021 Apr;28(4):397-403. doi: 10.1111/iju.14476. Epub 2020 Dec 29.
To assess the relationship between visceral fat accumulation and lower urinary tract symptoms in female patients.
In this single-center study, we enrolled all women who underwent screening abdominal computed tomography 3 months before the study, irrespective of whether they experienced lower urinary tract symptoms. The Overactive Bladder Symptom Score was used to assess subjective symptoms. Uroflowmetry and ultrasound assessment of post-void residual urine were carried out to assess objective signs. We analyzed the relationship between lower urinary tract symptoms and various body fat accumulation parameters, including visceral fat area, visceral fat volume and total abdominal fat volume, assessed using computed tomography scans.
A total of 182 patients were divided into the overactive bladder (n = 71, 39.0%) and the non-overactive bladder (n = 111, 61.0%) groups. The visceral fat area, visceral fat volume and visceral fat volume/total abdominal fat volume values were all significantly higher in the overactive bladder group than in the non-overactive bladder group (P < 0.001). Of these parameters, the visceral fat volume/total abdominal fat volume ratio showed the strongest correlation with the total Overactive Bladder Symptom Score (r = 0.394, P < 0.001). The maximum urine flow rate correlated negatively with the visceral fat volume/total abdominal fat volume value (visceral fat volume/total abdominal fat volume r = -0.289, P < 0.001). Subsequent multivariate analysis showed that a high visceral fat volume/total abdominal fat volume value, age and metabolic syndrome-related diseases were independent risk factors for the presence of overactive bladder.
Excessive accumulation of visceral fat is independently associated with overactive bladder in females.
评估女性患者内脏脂肪堆积与下尿路症状之间的关系。
在这项单中心研究中，我们纳入了所有在研究前 3 个月接受过腹部计算机断层扫描筛查的女性患者，无论其是否存在下尿路症状。采用膀胱过度活动症症状评分评估主观症状，通过尿流率和超声评估残余尿量来评估客观体征。我们分析了下尿路症状与各种体脂堆积参数之间的关系，包括使用计算机断层扫描评估的内脏脂肪面积、内脏脂肪体积和全腹脂肪体积。
共纳入 182 例患者，分为膀胱过度活动症组（n=71，39.0%）和非膀胱过度活动症组（n=111，61.0%）。膀胱过度活动症组的内脏脂肪面积、内脏脂肪体积和内脏脂肪体积/全腹脂肪体积均明显高于非膀胱过度活动症组（P<0.001）。在这些参数中，内脏脂肪体积/全腹脂肪体积比值与总的膀胱过度活动症症状评分相关性最强（r=0.394，P<0.001）。最大尿流率与内脏脂肪体积/全腹脂肪体积值呈负相关（内脏脂肪体积/全腹脂肪体积 r=-0.289，P<0.001）。随后的多因素分析显示，高内脏脂肪体积/全腹脂肪体积值、年龄和代谢综合征相关疾病是膀胱过度活动症存在的独立危险因素。
女性内脏脂肪过度堆积与膀胱过度活动症独立相关。
