Shrestha B
Department of Microbiology, Tri-Chandra Campus, Tribhuvan University, Nepal.
J Nepal Health Res Counc. 2013 Sep;11(25):305-12.
Panton Valentine leukocidin is a toxin making pores in the polymorphonuclear cells which is a virulence factor of some strains of Staphylococcus aureus. Initially it was produced by methicillin susceptible Staphylococcus aureus only. Later with the acquisition of mecA gene has lead it to be PVL positive methicillin resistant Staphylococcus aureus. Since MRSA are resistant to many antibiotics and further they produce a toxin the infections by PVL positive MRSA has become a challenge. PVL positive MRSA a virulent strain of drug resistant superbug MRSA that has spread around the world, has claimed many lives in UK, Europe, USA and Australia. Some strains of superbug attack the healthy young people and kill within 24 hrs. PVL positive Staphylococcus aureus has been reported to be associated with skin and soft tissue infections however they also cause invasive infections and necrotizing pneumonia. These microorganisms known to be community associated have spread to hospitals. Hospital acquired infection by such microorganisms lead to an increase in mortality hence should be controlled before they become prevalent in hospitals.
潘顿-瓦伦丁杀白细胞素是一种可在多形核细胞中形成孔道的毒素，它是某些金黄色葡萄球菌菌株的毒力因子。最初它仅由对甲氧西林敏感的金黄色葡萄球菌产生。后来随着mecA基因的获得，导致其成为PVL阳性的耐甲氧西林金黄色葡萄球菌。由于耐甲氧西林金黄色葡萄球菌对多种抗生素耐药，并且它们还产生毒素，PVL阳性耐甲氧西林金黄色葡萄球菌引起的感染已成为一项挑战。PVL阳性耐甲氧西林金黄色葡萄球菌是耐药超级细菌耐甲氧西林金黄色葡萄球菌的一种毒力菌株，已在全球传播，在英国、欧洲、美国和澳大利亚已夺去许多人的生命。一些超级细菌菌株会攻击健康的年轻人，并在24小时内致人死亡。据报道，PVL阳性金黄色葡萄球菌与皮肤和软组织感染有关，但它们也会引起侵袭性感染和坏死性肺炎。这些已知与社区相关的微生物已传播到医院。此类微生物引起的医院获得性感染会导致死亡率上升，因此在它们在医院中普遍流行之前应加以控制。
