Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
Sci Total Environ. 2014 Aug 15;490:934-40. doi: 10.1016/j.scitotenv.2014.05.058. Epub 2014 Jun 6.
Our objective is to evaluate the association of exposure to traffic-related air pollution with the incidence of fatal and non-fatal ischemic heart disease (IHD), stroke and total cardiovascular disease (CVD) events in a Greek cohort. We used data from the European Prospective Investigation on Nutrition and Cancer (EPIC) for 2752 subjects followed from 1997 to 2011, whose residence was in 10 municipalities of the Greater Athens area. Air pollution exposure estimation was based on a spatio-temporal land use regression model linking geo-coded residential addresses to long-term average NO2 and PM10 concentrations. We conducted Cox proportional hazards regression analysis, adjusting for potential confounders. Hazard ratios (HR) above 1 (not all statistically significant) were associated with higher PM10 exposure for all outcomes. Weaker associations were found with NO2 exposure. Specifically, the estimated HR for a CVD event associated with 10 μg/m(3) increase in long-term exposure to PM10 was 1.50 (1.05-2.16, p-value: 0.027). The relationship was more evident for subjects ≤50 years old at recruitment. Associations of PM10 and NO2 exposure with IHD events were found only among women with HRs respectively of 2.24 (0.89-5.64, p-value: 0.086) and 1.54 (1.01-2.37, p-value: 0.046) associated with 10 μg/m(3) increase in the corresponding pollutant. In conclusion, the present study suggests that long-term exposure to traffic-related air pollution has an impact on CVD and IHD morbidity, particularly among women and younger subjects.
我们的目的是评估接触与交通相关的空气污染与致命和非致命缺血性心脏病（IHD）、中风和总心血管疾病（CVD）事件的发生率之间的关联，该研究队列来自希腊。我们使用了欧洲前瞻性营养与癌症研究（EPIC）的数据，该研究共纳入了 2752 名参与者，随访时间从 1997 年到 2011 年，这些参与者的居住地位于大雅典地区的 10 个城市。空气污染暴露的评估是基于一个时空土地利用回归模型，将地理编码的居住地址与长期平均 NO2 和 PM10 浓度联系起来。我们进行了 Cox 比例风险回归分析，调整了潜在的混杂因素。所有结果中，PM10 暴露量高于 1（并非所有结果均有统计学意义）与更高的风险比（HR）相关。与 NO2 暴露相关的关联较弱。具体来说，与 CVD 事件相关的 10 μg/m3 长期 PM10 暴露增加的估计 HR 为 1.50（1.05-2.16，p 值：0.027）。在招募时年龄≤50 岁的受试者中，这种关系更为明显。仅在女性中发现了 PM10 和 NO2 暴露与 IHD 事件之间的关联，其 HR 分别为 2.24（0.89-5.64，p 值：0.086）和 1.54（1.01-2.37，p 值：0.046），与相应污染物增加 10 μg/m3 相关。总之，本研究表明，长期接触与交通相关的空气污染对 CVD 和 IHD 的发病率有影响，特别是在女性和年轻人群中。
