Leuchter A F, Walter D O
UCLA Neuropsychiatric Institute and Hospital.
Int Psychogeriatr. 1989 Spring;1(1):63-72. doi: 10.1017/s1041610289000062.
Functional brain imaging using computer-analyzed electroencephalography was performed in 40 subjects: 15 with mild-to-moderate dementia of the Alzheimer's type (DAT), 13 with mild-to-moderate multi-infarct dementia (MID), and 12 age-matched controls. We examined three different parameters of brain electrical activity in these subjects: absolute slow-wave power, proportional power in all frequency bands, and ratios of high-frequency/low-frequency electrical activity (so-called "spectral ratios"). Spectral ratios were significantly more powerful in discriminating among groups than the other measures. Functional images using spectral ratios revealed that subjects with DAT have a characteristic left temporo-parietal defect which clearly distinguished them from subjects with MID and from control subjects. The severity of dementia was best assessed by examining absolute slow-wave power, which had the strongest linear correlation with mental status testing. Serial images from one subject with DAT over 3 years demonstrate both quantitative and qualitative shifts in slow-wave activity in the course of DAT. The study suggests that functional imaging may be more useful than either simple EEG or computer-analyzed EEG in assessing and diagnosing patients with suspected dementia.
对40名受试者进行了使用计算机分析脑电图的功能性脑成像研究：15名患有轻度至中度阿尔茨海默病型痴呆（DAT），13名患有轻度至中度多发梗死性痴呆（MID），以及12名年龄匹配的对照者。我们检查了这些受试者脑电活动的三个不同参数：绝对慢波功率、所有频段的比例功率以及高频/低频电活动比率（所谓的“频谱比率”）。频谱比率在区分不同组之间比其他测量方法更具效力。使用频谱比率的功能图像显示，患有DAT的受试者有特征性的左侧颞顶叶缺陷，这使其与患有MID的受试者以及对照者明显区分开来。通过检查绝对慢波功率可以最好地评估痴呆的严重程度，其与精神状态测试的线性相关性最强。一名患有DAT的受试者在3年期间的系列图像显示了DAT病程中慢波活动的定量和定性变化。该研究表明，在评估和诊断疑似痴呆患者时，功能性成像可能比单纯脑电图或计算机分析脑电图更有用。
