Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, UK; Centre for Cellular and Molecular Physiology, Old Road Campus, University of Oxford, Oxford, UK.
Am J Transplant. 2014 Jul;14(7):1481-7. doi: 10.1111/ajt.12737. Epub 2014 Jun 6.
Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors that activate a number of hypoxia responsive genes, some of which are responsible for protective cellular functions. During organ donation, allografts are exposed to significant periods of hypoxia and ischemia. Exploiting this pathway during donor management and organ preservation could prevent and reduce allograft injury and improve the outcomes of organ transplantation. We review the evidence on this pathway in organ preservation, drawing on experimental studies on donor management and ischemia reperfusion injury focusing on kidney, liver, cardiac and lung transplantation. We review the major technical and experimental challenges in exploring this pathway and suggest potential future avenues for research.
缺氧诱导因子是普遍存在的细胞氧敏感转录因子，可激活许多缺氧反应基因，其中一些基因负责保护细胞功能。在器官捐献过程中，同种异体移植物会经历长时间的缺氧和缺血。在供者管理和器官保存过程中利用这一途径可以预防和减少移植物损伤，改善器官移植的效果。我们通过对供者管理和缺血再灌注损伤的实验研究，回顾了该途径在器官保存中的证据，重点关注肾、肝、心和肺移植。我们回顾了探索这一途径的主要技术和实验挑战，并提出了潜在的未来研究方向。
