Aiso Shigetoshi, Take Makoto, Kasai Tatsuya, Senoh Hideki, Umeda Yumi, Matsumoto Michiharu, Fukushima Shoji
Japan Bioassay Research Center, Japan Industrial Safety and Health Association , Kanagawa , Japan.
Inhal Toxicol. 2014 Jul;26(8):435-51. doi: 10.3109/08958378.2014.905660. Epub 2014 Jun 9.
The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar-alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.
通过将50只F344/DuCrj大鼠和50只Crj:BDF1小鼠（雌雄各半）暴露于含0、1000、2000或4000 ppm（w/w）二氯甲烷（DCM）的气溶胶中2年，来检测吸入DCM的致癌性。吸入DCM导致雄性大鼠皮下纤维瘤、乳腺纤维腺瘤和腹膜间皮瘤的发生率增加；雌性大鼠乳腺纤维腺瘤的发生率增加；雄性和雌性小鼠肺细支气管肺泡腺瘤和癌以及肝细胞腺瘤和癌的发生率增加。这些结果清楚地表明，吸入DCM对F344/DuCrj（SPF）大鼠和Crj:BDF1（SPF）小鼠具有致癌性。
