Kahveci K, Ornek D, Doger C, Aydin G B, Aksoy M, Emre C, Deveci A, Bozkurt M, Ozgun G
Departments of Anesthesiology, Ataturk Training and Research Hospital, Ankara, Turkey.
Niger J Clin Pract. 2014 Jul-Aug;17(4):523-7. doi: 10.4103/1119-3077.134058.
The aim of this study was to investigate the effect of different types of anesthesia on stress hormones.
The study was included 60 ASAI-II cases scheduled for major lower extremity surgery. The cases were randomized into 2 groups: The EA group was administered epidural anesthesia and the GA group was administered standard general anesthesia. In order to evaluate the surgical trauma - related stress response, CRP, TSH, cortisol, and fasting blood sugar(FBS) levels were measured preoperatively, 30 min after surgical incision, and 24 h post surgery.
Between-group comparisons; Preoperative values were not significantly different between the groups.( P > 0,05) Pulse rate and cortisol values significantly higher in general group at 30 min. ( P < 0,05), and the FBS values were significantly higher in the epidural group at 24 h.( P < 0,05) There were not found differences for other parameters at evaluation times.
No differences were observed between the two anesthesia methods, in terms of minimizing the stress response due to surgical trauma during major low extremity surgery.
本研究旨在探讨不同类型麻醉对应激激素的影响。
本研究纳入60例拟行下肢大手术的ASA I-II级患者。将患者随机分为2组：硬膜外麻醉组（EA组）采用硬膜外麻醉，全身麻醉组（GA组）采用标准全身麻醉。为评估手术创伤相关应激反应，于术前、手术切口后30分钟及术后24小时测量CRP、TSH、皮质醇和空腹血糖（FBS）水平。
组间比较；术前两组间数值无显著差异（P>0.05）。全身麻醉组在30分钟时脉搏率和皮质醇值显著更高（P<0.05），硬膜外麻醉组在24小时时FBS值显著更高（P<0.05）。在评估时间点，其他参数未发现差异。
在下肢大手术中，两种麻醉方法在最小化手术创伤引起的应激反应方面未观察到差异。
