Huang Pei-Yu, Zhong Zong-Liang, Luo Dong-Hua, Mai Hai-Qiang, Chen Ming-Yuan, Li Yan-Xian, Yang Jing, Mo Hao-Yuan
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou.
Acta Otolaryngol. 2014 Aug;134(8):824-30. doi: 10.3109/00016489.2014.913312. Epub 2014 Jun 9.
The prognosis and late adverse effects of radiotherapy (RT) in the patients with nasopharyngeal carcinoma (NPC) with or without dermatomyositis (DM) were similar, although the NPC patients with DM had higher Epstein-Barr virus (EBV) VCA-IgA titers and more severe acute side effects. Gender, TNM stage, and chemotherapy were independent prognostic factors of overall survival for NPC with DM. Glucocorticoid treatment did not affect the survival of NPC patients with DM.
We evaluated the clinical characteristics, prognosis, and differences in the toxicity of RT in patients with NPC with or without DM.
A paired study of 172 NPC cases with DM (DM group) or without DM (control group) from Sun Yat-sen University Cancer Center was conducted.
The DM group had higher EBV VCA-IgA titers than the control group (p = 0.017) and more acute adverse effects of RT (p < 0.001). No significant differences in the overall survival or late adverse effects were found between the two groups. Gender, TNM stage, and chemotherapy were independent prognostic factors for the overall survival in the DM group. No significant differences in the overall survival were found between the patients in the DM group who were taking glucocorticoids and those who were not.
鼻咽癌（NPC）伴或不伴皮肌炎（DM）患者放疗（RT）的预后及晚期不良反应相似，尽管伴DM的NPC患者的爱泼斯坦-巴尔病毒（EBV）VCA-IgA滴度更高且急性副作用更严重。性别、TNM分期及化疗是伴DM的NPC患者总生存的独立预后因素。糖皮质激素治疗不影响伴DM的NPC患者的生存。
我们评估了伴或不伴DM的NPC患者的临床特征、预后及放疗毒性差异。
对中山大学肿瘤防治中心172例伴DM的NPC患者（DM组）和不伴DM的NPC患者（对照组）进行配对研究。
DM组的EBV VCA-IgA滴度高于对照组（p = 0.017），且放疗的急性不良反应更多（p < 0.001）。两组在总生存或晚期不良反应方面未发现显著差异。性别、TNM分期及化疗是DM组总生存的独立预后因素。在伴DM的患者中，服用糖皮质激素的患者与未服用糖皮质激素的患者在总生存方面未发现显著差异。
