University of Tennessee Medical School, Memphis, Tennessee.
Division of Rheumatology, University of Tennessee Health Science Center, Memphis, Tennessee.
Am J Med Sci. 2020 Oct;360(4):402-405. doi: 10.1016/j.amjms.2020.05.011. Epub 2020 May 13.
Dermatomyositis is an inflammatory disorder involving muscle and skin. Similar to many other autoimmune diseases, environmental factors appear to trigger the onset of disease in some cases. Many drugs have been reported to be associated with dermatomyositis, and rarely infections have been described as potential triggering agents. Here we are describing a case of dermatomyositis that developed after doxycycline and levofloxacin use, who also had recent Epstein-Barr virus infection. Dermatomyositis associated with doxycycline or levofloxacin use has not yet been described in the literature, while reports of dermatomyositis after Epstein-Barr virus infection have been rare and limited to juvenile dermatomyositis or in association with cancer. It is important for clinicians to be aware of this rare association so that the diagnosis and treatment can be exercised promptly.
皮肌炎是一种涉及肌肉和皮肤的炎症性疾病。与许多其他自身免疫性疾病类似，在某些情况下，环境因素似乎会引发疾病的发作。据报道，许多药物与皮肌炎有关，很少有感染被描述为潜在的触发因素。在这里，我们描述了一例在使用多西环素和左氧氟沙星后发生的皮肌炎病例，该患者最近还感染了 EBV（Epstein-Barr virus，即人类疱疹病毒 4 型）。文献中尚未描述与多西环素或左氧氟沙星使用相关的皮肌炎，而 EBV 感染后发生皮肌炎的报道很少且仅限于青少年皮肌炎或与癌症相关。临床医生了解这种罕见的关联非常重要，以便能够及时进行诊断和治疗。
