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获得平等的医疗保健服务可能会缩小1型糖尿病本土患者和移民患者之间的治疗效果差异。

Equal access to health care may diminish the differences in outcome between native and immigrant patients with type 1 diabetes.

作者信息

Fredheim Siri, Delli Ahmed, Rida Heba, Drivvoll Ann-Kristin, Skrivarhaug Torild, Bjarnason Ragnar, Thorsson Arni, Lindblad Bengt, Svensson Jannet

机构信息

Department of Pediatrics, Herlev Hospital, Herlev, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Pediatr Diabetes. 2014 Nov;15(7):519-27. doi: 10.1111/pedi.12157. Epub 2014 Jun 9.

Abstract

BACKGROUND/OBJECTIVE: Previous studies have found that ethnicity influences glycemic control. We hypothesized that differences between Nordic and non-Nordic patients are less pronounced for children with type 1 diabetes in high incidence countries in Northern Europe.

RESEARCH DESIGN AND METHODS

We investigated patients aged 0-15 yr in national pediatric registers in Denmark (D), Iceland (I), Norway (N), and Sweden (S) (2006-2009). Ethnic origin was defined by maternal country of birth as being Nordic or non-Nordic (other countries).

RESULTS

The cohort (n = 11,908, 53.0% boys, onset age 7.7 (3.9) yr, diabetes duration 6.1 (3.6) yr, [mean, (SD)]) comprised 921 (7.7%) non-Nordic patients. The frequencies of non-Nordic patients according to country of residence were: 5.7% (D), 2.7% (I), 5.5% (N), and 9.4% (S). Sex distribution and BMI z-score did not differ between Nordic and non-Nordic patients, but non-Nordic patients were 0.5 yr younger at onset than Nordic patients (p < 0.0006). Non-Nordic patients had a lower number of daily insulin bolus injections and higher daily insulin doses compared to their Nordic peers. Patients of non-Nordic origin had slightly higher HbA1c levels (0.6-2.9 mmol/mol, p < 0.001) and, with the exception of Norway, were less frequently treated with CSII (p = 0.002) after adjusting for confounders.

CONCLUSIONS

The reported differences in glycemic regulation between Nordic and non-Nordic type 1 diabetes children and adolescents in four Nordic countries are diminutive, but persist after accounting for treatment intensity.

摘要

背景/目的:既往研究发现种族会影响血糖控制。我们推测,在北欧高发病率国家,1型糖尿病儿童中北欧和非北欧患者之间的差异不那么明显。

研究设计与方法

我们调查了丹麦(D)、冰岛(I)、挪威(N)和瑞典(S)国家儿科登记处中0至15岁的患者(2006 - 2009年)。种族起源根据母亲的出生国定义为北欧或非北欧(其他国家)。

结果

该队列(n = 11,908,53.0%为男孩,发病年龄7.7(3.9)岁,糖尿病病程6.1(3.6)年,[均值,(标准差)])包括921名(7.7%)非北欧患者。根据居住国划分的非北欧患者频率分别为:5.7%(丹麦)、2.7%(冰岛)、5.5%(挪威)和9.4%(瑞典)。北欧和非北欧患者的性别分布和BMI z评分没有差异,但非北欧患者发病时比北欧患者小0.5岁(p < 0.0006)。与北欧同龄人相比,非北欧患者每日胰岛素推注次数较少,每日胰岛素剂量较高。在调整混杂因素后,非北欧血统的患者HbA1c水平略高(0.6 - 2.9 mmol/mol),除挪威外,接受持续皮下胰岛素输注(CSII)治疗的频率较低(p = 0.002)。

结论

在四个北欧国家,报告的北欧和非北欧1型糖尿病儿童及青少年在血糖调节方面的差异很小,但在考虑治疗强度后仍然存在。

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