Fujita Yu, Yoshioka Yusuke, Ito Saburo, Araya Jun, Kuwano Kazuyoshi, Ochiya Takahiro
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan; Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Clin Ther. 2014 Jun 1;36(6):873-81. doi: 10.1016/j.clinthera.2014.05.006. Epub 2014 Jun 6.
Extracellular vesicles (EVs) such as exosomes and microvesicles are phospholipid bilayer-enclosed vesicles that are recognized as novel tools for intercellular communications and as biomarkers for several diseases. They contain various DNAs, proteins, mRNAs, and microRNAs (miRNAs) that have potential diagnostic and therapeutic purposes. Their biological roles have attracted significant interest in the pulmonary field because their vesicle composition and miRNA content have the ability to transfer biological information to recipient cells and play an important role in pulmonary inflammatory and allergic diseases. Asthma is a chronic inflammatory disease of the airways, and it is characterized by variable and recurring symptoms and reversible airflow obstruction. The purpose of this review was to discuss the function of EVs and their miRNAs in asthma, with a focus on the biological properties and biogenesis of EVs, their pathophysiologic roles, and their potential use as biomarkers and therapies for asthma.
We review the findings from several articles on EVs and their miRNAs in asthma and provide illustrative references.
A few studies have reported on the biological function of bronchoalveolar lavage fluid-derived EVs in asthmatic progression. In the lungs, EVs might regulate airway inflammation and allergic reactions through their paracrine effects. Furthermore, circulating miRNAs have been found to be associated with EVs.
EV-mediated miRNAs can be used as biomarkers in asthma.
细胞外囊泡（EVs），如外泌体和微囊泡，是由磷脂双分子层包裹的囊泡，被认为是细胞间通讯的新型工具以及多种疾病的生物标志物。它们包含各种具有潜在诊断和治疗用途的DNA、蛋白质、信使核糖核酸（mRNA）和微小核糖核酸（miRNA）。它们的生物学作用在肺部领域引起了极大的关注，因为其囊泡成分和miRNA含量能够将生物信息传递给受体细胞，并在肺部炎症和过敏性疾病中发挥重要作用。哮喘是一种气道慢性炎症性疾病，其特征为症状多变且反复出现以及气流可逆性受阻。本综述的目的是讨论EVs及其miRNA在哮喘中的作用，重点关注EVs的生物学特性和生物发生、其病理生理作用以及它们作为哮喘生物标志物和治疗方法的潜在用途。
我们回顾了几篇关于哮喘中EVs及其miRNA的研究结果，并提供了说明性参考文献。
一些研究报道了支气管肺泡灌洗液来源的EVs在哮喘进展中的生物学功能。在肺部，EVs可能通过其旁分泌作用调节气道炎症和过敏反应。此外，已发现循环miRNA与EVs有关。
EV介导的miRNA可作为哮喘的生物标志物。
