Department of Neurology, Medical University of Vienna, Vienna, Austria.
Eur J Neurol. 2014 Oct;21(10):1276-84, e77. doi: 10.1111/ene.12470. Epub 2014 Jun 9.
The goal of this study was to establish the prevalence of subjective memory complaints (SMCs) and depressive symptoms (DS)s and their relation to cognitive functioning in patients with Parkinson's disease (PD).
In all, 248 controls and 104 PD patients were included in the study. The PD group was subdivided into three PD subtypes with mild cognitive impairment (MCI) according to the Petersen criteria and three PD subtypes with MCI according to the Litvan criteria.
Substantial SMCs were reported by 7.7% of controls and 16.3% of the PD patients (P < 0.001). A clinically relevant degree of DSs was evident in 16.6% of controls compared with 40.4% in the PD group (P < 0.001). An analysis of variance revealed a statistically significant difference for SMCs across all Petersen groups as well across all Litvan groups. Two-factor analyses of variance with the factors cognitive status (MCI subtype) and depressive state (depressed versus not depressed) and SMCs as dependent variable revealed significant results.
Approximately 15% of PD patients seeking help in a movement disorder clinic report significant SMCs, with an increasing degree from cognitively healthy PD to PD-MCI. Significant DSs increase SMCs across all cognitive status groups.
本研究旨在确定帕金森病（PD）患者主观记忆主诉（SMC）和抑郁症状（DS）的患病率及其与认知功能的关系。
共纳入 248 名对照者和 104 名 PD 患者。PD 组根据 Petersen 标准分为三个轻度认知障碍（MCI）亚组，根据 Litvan 标准分为三个 MCI 亚组。
对照组中有 7.7%报告有明显的 SMC，PD 患者中有 16.3%（P<0.001）。对照组中有 16.6%出现明显的 DS，而 PD 组中有 40.4%（P<0.001）。方差分析显示，所有 Petersen 组和所有 Litvan 组的 SMC 存在统计学差异。以 SMC 为因变量，采用认知状态（MCI 亚型）和抑郁状态（抑郁与不抑郁）的两因素方差分析显示有显著结果。
大约 15%寻求运动障碍诊所帮助的 PD 患者报告有明显的 SMC，从认知健康的 PD 到 PD-MCI 程度逐渐增加。明显的 DS 会增加所有认知状态组的 SMC。
