Department of Neurology, Medical University of Vienna, Vienna, Austria.
Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Int Psychogeriatr. 2014 Mar;26(3):463-73. doi: 10.1017/S1041610213002263. Epub 2013 Dec 5.
The goals of this study were to establish prevalence of subjective memory complaints (SMC) and depressive symptoms (DS) and their relation to cognitive functioning and cognitive status in an outpatient memory clinic cohort.
Two hundred forty-eight cognitively healthy controls and 581 consecutive patients with cognitive complaints who fulfilled the inclusion criteria were included in the study.
A statistically significant difference (p < 0.001) between control group and patient group regarding mean SMC was detected. 7.7% of controls reported a considerable degree of SMC, whereas 35.8% of patients reported considerable SMC. Additionally, a statistically significant difference (p < 0.001) between controls and patient group regarding Beck depression score was detected. 16.6% of controls showed a clinical relevant degree of DS, whereas 48.5% of patients showed DS. An analysis of variance revealed a statistically significant difference across all four groups (control group, SCI group, naMCI group, aMCI group) (p < 0.001). Whereas 8% of controls reported a considerable degree of SMC, 34% of the SCI group, 31% of the naMCI group, and 54% of the aMCI group reported considerable SMC. A two-factor analysis of variance with the factors cognitive status (controls, SCI group, naMCI group, aMCI group) and depressive status (depressed vs. not depressed) and SMC as dependent variable revealed that both factors were significant (p < 0.001), whereas the interaction was not (p = 0.820).
A large proportion of patients seeking help in a memory outpatient clinic report considerable SMC, with an increasing degree from cognitively healthy elderly to aMCI. Depressive status increases SMC consistently across groups with different cognitive status.
本研究旨在确定主观记忆主诉（SMC）和抑郁症状（DS）的患病率，以及它们与认知功能和认知状态在门诊记忆诊所队列中的关系。
本研究纳入了 248 名认知健康的对照组和 581 名符合纳入标准的认知障碍患者。
对照组和患者组在平均 SMC 方面存在显著差异（p<0.001）。对照组中有 7.7%的人报告了相当程度的 SMC，而患者组中有 35.8%的人报告了相当程度的 SMC。此外，对照组和患者组在贝克抑郁评分方面也存在显著差异（p<0.001）。对照组中有 16.6%的人表现出临床相关程度的 DS，而患者组中有 48.5%的人表现出 DS。方差分析显示，所有四个组（对照组、SCI 组、naMCI 组、aMCI 组）之间存在显著差异（p<0.001）。对照组中有 8%的人报告了相当程度的 SMC，而 SCI 组中有 34%、naMCI 组中有 31%、aMCI 组中有 54%的人报告了相当程度的 SMC。以 SMC 为因变量，以认知状态（对照组、SCI 组、naMCI 组、aMCI 组）和抑郁状态（抑郁与不抑郁）为因子的双因素方差分析显示，两个因子均具有统计学意义（p<0.001），而交互作用无统计学意义（p=0.820）。
在记忆门诊寻求帮助的患者中，相当大一部分人报告了相当程度的 SMC，从认知健康的老年人到 aMCI，程度逐渐增加。抑郁状态在具有不同认知状态的组中一致增加 SMC。
