Rao K Srinivasa, Gehlot Praveen Singh, Trivedi Tushar J, Kumar Arvind
Academy of Scientific and Innovative Research (AcSIR), Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, India.
Academy of Scientific and Innovative Research (AcSIR), Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, India; Salt & Marine Chemicals Division, Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, India.
J Colloid Interface Sci. 2014 Aug 15;428:267-75. doi: 10.1016/j.jcis.2014.04.062. Epub 2014 May 4.
New anionic ionic liquid surfactants have been synthesized by replacing the sodium cation of Aerosol-OT (sodium dioctylsulfosuccinate, [Na]AOT) with various biocompatible moieties, such as 1-butyl-3-methyl imidazolium ([C4mim]), proliniumisopropylester ([ProC3]), cholinium ([Cho]), and guanidinium ([Gua]). The Aerosol-OT derived ionic liquids (AOT-ILs) were found fairly soluble in water and formed vesicles above a critical vesicle concentration (CVC) which depended upon the nature of cation, and followed the order: [ProC3]<[C4mim]<[Gua]<[Cho]<Na(+). The self-assembly process was characterized using surface tension (ST), isothermal titration calorimetry (ITC), conductivity, dynamic light scattering (DLS), nuclear magnetic resonance (NMR) and transmission electron microscopy (TEM). Unlike other AOT-ILs, a structural transformation has been observed for [C4mim]AOT above CVC, because of certain amphiphilic character in the cation [C4mim]. Thermodynamic parameters calculated from ITC and conductivity techniques revealed that the vesicle formation process is entropy driven for [C4mim]AOT, whereas the process is both enthalpy and entropy driven for other AOT-ILs. In order to check the versatility of synthesized AOT-ILs we have tested their dissolution behavior in a different class of ionic liquids. All the AOT-ILs were found fairly soluble in the hydrophilic IL, ethanolammonium formate (EOAF), whereas only [C4mim]AOT and [ProC3]AOT were found soluble in hydrophobic IL, [C4mim]Tf2N. Such combinations can have potential for construction of stable colloidal formulations or microemulsions in ionic liquid media.
通过用各种生物相容性部分取代气溶胶-OT（二辛基磺基琥珀酸钠，[Na]AOT）的钠离子，合成了新型阴离子离子液体表面活性剂，这些生物相容性部分包括1-丁基-3-甲基咪唑鎓（[C4mim]）、脯氨酸异丙酯（[ProC3]）、胆碱鎓（[Cho]）和胍鎓（[Gua]）。发现气溶胶-OT衍生的离子液体（AOT-ILs）在水中相当易溶，并且在高于临界囊泡浓度（CVC）时形成囊泡，临界囊泡浓度取决于阳离子的性质，顺序为：[ProC3]<[C4mim]<[Gua]<[Cho]<Na(+)。使用表面张力（ST）、等温滴定量热法（ITC）、电导率、动态光散射（DLS）、核磁共振（NMR）和透射电子显微镜（TEM）对自组装过程进行了表征。与其他AOT-ILs不同，由于阳离子[C4mim]具有一定的两亲性，在高于CVC时观察到[C4mim]AOT发生了结构转变。从ITC和电导率技术计算得到的热力学参数表明，[C4mim]AOT的囊泡形成过程是熵驱动的，而其他AOT-ILs的过程是焓和熵共同驱动的。为了检验合成的AOT-ILs的通用性，我们测试了它们在不同类离子液体中的溶解行为。发现所有AOT-ILs在亲水性离子液体甲酸乙醇铵（EOAF）中相当易溶，而仅[C4mim]AOT和[ProC3]AOT在疏水性离子液体[C4mim]Tf2N中可溶。这种组合在离子液体介质中构建稳定的胶体配方或微乳液方面具有潜力。
