Departamento de Química, Universidad Nacional de Rio Cuarto, Agencia Postal 3, C.P. X5804BYA, Ruta Nacional 36, km 601, Rio Cuarto, Córdoba, Argentina.
Instituto de Desarrollo Agroindustrial y de la Salud (IDAS), Universidad Nacional de Río Cuarto, Agencia Postal 3, C.P. X5804BYA, Ruta Nacional 36, km 601, Río Cuarto, Córdoba, Argentina.
Pharm Res. 2022 Oct;39(10):2379-2390. doi: 10.1007/s11095-022-03342-7. Epub 2022 Jul 19.
The present review describes the state of the art in the conversion of pharmaceutically active ingredients (API) in amphiphilic Ionic Liquids (ILs) as alternative drug delivery systems. In particular, we focus our attention on the compounds generated by ionic exchange and without original counterions which generate different systems in comparison with the simple mixtures. In water, these new amphiphiles show similar or even better properties as surfactants in comparison with their precursors. Cations such as 1-alkyl-3-methyl-imidazolium and anions such as dioctyl sulfosuccinate or sodium dodecyl sulfate appear as the amphiphilic components most studied. In conclusion, this work shows interesting information on several promissory compounds and they appear as an interesting challenge to extend the application of ILs in the medical field.
本综述描述了将药用活性成分 (API) 转化为两亲性离子液体 (IL) 作为替代药物传递系统的最新技术。特别是，我们将注意力集中在离子交换生成的化合物上，这些化合物没有原始的抗衡离子，与简单的混合物相比会产生不同的系统。在水中，与前体相比，这些新的两亲分子在作为表面活性剂方面表现出相似甚至更好的性质。像 1-烷基-3-甲基-咪唑鎓阳离子和二辛基琥珀酸酯或十二烷基硫酸钠阴离子这样的阳离子和阴离子似乎是研究最多的两亲性成分。总之，这项工作展示了一些有前途的化合物的有趣信息，它们似乎是一个有趣的挑战，将 ILs 在医学领域的应用扩展。
