Wylie Matthew P, Bell Steven E J, Nockemann Peter, Bell Rory, McCoy Colin P
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, U.K.
School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, U.K.
ACS Omega. 2020 Apr 1;5(14):7771-7781. doi: 10.1021/acsomega.9b03528. eCollection 2020 Apr 14.
Microbial fouling is a costly issue, which impacts a wide range of industries, such as healthcare, food processing, and construction industries, and improved strategies to reduce the impact of fouling are urgently required. Slippery liquid-infused porous surfaces (SLIPSs) have recently been developed as a bioinspired approach to prevent antifouling. Here, we report the development of slippery, superhydrophilic surfaces by infusing roughened poly(vinyl chloride) (PVC) substrates with phosphonium ionic liquids (PILs). These surfaces were capable of reducing viable bacterial adherence by and by >6 log cfu mL after 24 h under static conditions relative to control PVC. Furthermore, we report the potential of a series of asymmetric quaternary alkyl PILs with varying alkyl chain lengths (C-C) and counteranions to act as antimicrobial agents against both Gram +ve and Gram -ve bacteria and illustrate their potential as antimicrobial alternatives to traditional fluorinated lubricants commonly used in the synthesis of SLIPSs.
微生物污垢是一个代价高昂的问题，它影响着广泛的行业，如医疗保健、食品加工和建筑行业，因此迫切需要改进策略以减少污垢的影响。最近，注入滑液的多孔表面（SLIPSs）作为一种受生物启发的防污方法被开发出来。在这里，我们报告了通过将粗糙的聚氯乙烯（PVC）基材注入鏻离子液体（PILs）来制备光滑、超亲水表面的方法。相对于对照PVC，在静态条件下24小时后，这些表面能够将活菌粘附减少 ，并使>6 log cfu/mL。此外，我们报告了一系列具有不同烷基链长度（C-C）和抗衡阴离子的不对称季铵烷基PILs作为抗革兰氏阳性菌和革兰氏阴性菌抗菌剂的潜力，并说明了它们作为传统氟化润滑剂的抗菌替代品的潜力，这些传统氟化润滑剂常用于合成SLIPSs。
