Hergueta García de Guadiana G, Paumard Fraguas A
An Med Interna. 1989 Jan;6(1):15-8.
A close comparative study of the hypotensive effects of verapamil and chlorthalidone was carried out on 60 patients affected with mild essential hypertension showing systemic. I-II OMS affectation degree, during 9 weeks. Both, the calcium channel blockers and the diuretics produced statistically significant decreases in the arterial pressure, being more evident with verapamil. An adequate control of the hypertension was achieved with both drugs, the results produced with verapamil (from 2nd week) being more important and quicker. The biochemical control did give the best results with verapamil, however, because it did not modify the plasmatic levels of cholesterol, uric acid and potassium. We concluded that the calcium channel blocker must be included in the therapeutic arsenal against essential hypertension, verapamil being the first choice because of its efficacy, tolerance and minimal alterations o in the biochemical blood test.
对60例患有轻度原发性高血压且呈现全身性I-II级OMS病变程度的患者进行了为期9周的维拉帕米和氯噻酮降压效果的密切对比研究。钙通道阻滞剂和利尿剂均使动脉压产生了具有统计学意义的下降，维拉帕米的效果更明显。两种药物均实现了对高血压的充分控制，维拉帕米（从第2周起）产生的效果更显著且起效更快。然而，生化指标控制方面，维拉帕米取得了最佳效果，因为它未改变血浆胆固醇、尿酸和钾的水平。我们得出结论，钙通道阻滞剂必须纳入原发性高血压的治疗药物库中，维拉帕米因其疗效、耐受性以及对血液生化检测的最小影响而成为首选。
